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Streptozocin

Known as: Estreptozocina, Streptozotocin, N-D-Glucosyl-(2)-n'-nitrosomethylharnstoff 
A methylnitrosourea antineoplastic antibiotic isolated from the bacterium Streptomyces achromogenes. Streptozocin alkylates DNA, forming inter-strand… 
National Institutes of Health

Related topics

Related topics

27 relations

Narrower (7)

4,6-ethylidene glucose streptozotocinGANUMOF-Strep protocolZanosar
Alkylating Activity [MoA]Colorectal NeoplasmsDrug AllergyFAM-S protocol

Broader (2)

Antibiotics, AntineoplasticNitrosourea Compounds

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Antihyperglycemic, antihyperlipidemic and antioxidant activities of polysaccharides from Catathelasma ventricosum in streptozotocin-induced diabetic mice.
Highly Cited
1989
Highly Cited
1989
Studies on the mechanisms causing inhibition of insulin secretion in rat pancreatic islets exposed to human interleukin-1 beta indicate a perturbation in the mitochondrial function.
This study aimed at a more detailed characterization of the mechanisms by which interleukin 1 (IL-1) inhibits insulin secretion… 
Highly Cited
1984
Highly Cited
1984
Red Blood Cell Sorbitol as an Indicator of Polyol Pathway Activity: Inhibition by Sorbinil in Insulin-dependent Diabetic Subjects
In a double-blind crossover study of 15 diabetic patients, elevated red blood cell (RBC) sorbitol levels were reduced by oral… 
Highly Cited
1983
Highly Cited
1983
The effect of alloxan- and streptozotocin-induced diabetes on calcium transport in rat cardiac sarcoplasmic reticulum. The possible involvement of long chain acylcarnitines.
Isolated working hearts from diabetic rats have a decreased ability to respond to increasing preload or afterload. The ability of… 
Highly Cited
1983
Highly Cited
1983
Release of leukotriene B4 from human neutrophils and its relationship to degranulation induced by N-formyl-methionyl-leucyl-phenylalanine, serum-treated zymosan and the ionophore A23187.
The release of leukotriene B4 (LTB4) from human neutrophils and its relationship to degranulation induced by the divalent cation… 
Highly Cited
1982
Highly Cited
1982
Effect of diabetes mellitus on the regulation of enzyme secretion by isolated rat pancreatic acini.
The nature and mechanism of the pancreatic exocrine dysfunction in diabetes mellitus were evaluated in vitro using isolated… 
Highly Cited
1982
Highly Cited
1982
Restoration of Prostacyclin/Thromboxane A2 Balance in the Diabetic Rat: Influence of Dietary Vitamin E
The effect of dietary vitamin E on the synthesis of platelet thromboxane A2 (TxA2) and vascular prostacyclin (PGI2) in… 
Highly Cited
1980
Highly Cited
1980
Induction of diabetes by cumulative environmental insults from viruses and chemicals
Encephalomyocarditis virus (EMC) induces diabetes in certain inbred strains of mice by infecting and destroying pancreatic… 
Highly Cited
1977
Highly Cited
1977
Abnormal Regulation of Adrenal Function in Rats with Streptozotocin Diabetes
The factors that control adrenal steroid secretion and metabolism were investigated in rats made diabetic with Streptozotocin (65… 
Highly Cited
1972
Highly Cited
1972
Modulation of the feeding response to peripheral insulin, 2-deoxyglucose or 3-O-methyl glucose injection.
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