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Streptozocin

Known as: Estreptozocina, Streptozotocin, N-D-Glucosyl-(2)-n'-nitrosomethylharnstoff 
A methylnitrosourea antineoplastic antibiotic isolated from the bacterium Streptomyces achromogenes. Streptozocin alkylates DNA, forming inter-strand… 
National Institutes of Health

Related topics

Related topics

27 relations

Narrower (7)

4,6-ethylidene glucose streptozotocinGANUMOF-Strep protocolZanosar
Alkylating Activity [MoA]Colorectal NeoplasmsDrug AllergyFAM-S protocol

Broader (2)

Antibiotics, AntineoplasticNitrosourea Compounds

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
Insulin-dependent diabetes affects testicular function by FSH- and LH-linked mechanisms.
A study was conducted to form a unified hypothesis regarding the gonadotropin-related mechanisms that underlie alterations in the… 
Highly Cited
2003
Highly Cited
2003
Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells
Mouse embryonic stem (ES) cells differentiate into cells of all three primary germ layers including endodermal cells that produce… 
Highly Cited
2002
Highly Cited
2002
Pyridoxamine inhibits early renal disease and dyslipidemia in the streptozotocin-diabetic rat.
BACKGROUND Nonenzymatic reactions between sugars or lipids and protein and formation of advanced glycation and lipoxidation end… 
Highly Cited
2001
Highly Cited
2001
Effect of an antidiabetic extract of Catharanthus roseus on enzymic activities in streptozotocin induced diabetic rats.
Highly Cited
2000
Highly Cited
2000
Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC β inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes
Activation of protein kinase C (PKC) is implicated as an important mechanism by which diabetes causes vascular complications. We… 
Highly Cited
1996
Highly Cited
1996
Prevention of Islet Allograft Rejection with Engineered Myoblasts Expressing FasL in Mice
Allogeneic transplantation of islets of Langerhans was facilitated by the cotransplantation of syngeneic myoblasts genetically… 
Highly Cited
1993
Highly Cited
1993
Streptozocin-induced diabetic rats: behavioural evidence for a model of chronic pain
Highly Cited
1991
Highly Cited
1991
Retardation by Aminoguanidine of Development of Albuminuria, Mesangial Expansion, and Tissue Fluorescence in Streptozocin-Induced Diabetic Rat
This study evaluated the relationship between the development of fluorescence related to advanced glycosylation end products… 
Highly Cited
1990
Highly Cited
1990
Overexpression of fibronectin induced by diabetes or high glucose: phenomenon with a memory.
To identify events and mechanisms that might contribute to the poor reversibility of diabetic complications, we examined whether… 
Highly Cited
1987
Highly Cited
1987
Oral administration of vanadate normalizes blood glucose levels in streptozotocin-treated rats. Characterization and mode of action.
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