Sterol Regulatory Element Binding Protein 1

Known as: SREBP1 Protein, SREBF1, Sterol Regulatory Element Binding Protein 1 [Chemical/Ingredient] 
A sterol regulatory element binding protein that regulates expression of GENES involved in FATTY ACIDS metabolism and LIPOGENESIS. Two major isoforms… (More)
National Institutes of Health

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23 relations
Basic Helix-Loop-Helix Transcription FactorsCaspase Cascade PathwayCell NucleusGenes, Regulator
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Sterol Regulatory Element Binding Protein 1aSterol Regulatory Element Binding Protein 1c

Papers overview

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Highly Cited
2013
Highly Cited
2013
MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice
MicroRNAs (miRs) are small non-protein-coding RNAs that bind to specific mRNAs and inhibit translation or promote mRNA… (More)
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2010
2010
Sterol regulatory element binding protein and dietary lipid regulation of fatty acid synthesis in the mammary epithelium.
The lactating mammary gland synthesizes large amounts of triglyceride from fatty acids derived from the blood and from de novo… (More)
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2008
2008
Sterol regulatory element binding protein 1 interacts with pregnane X receptor and constitutive androstane receptor and represses their target genes.
OBJECTIVE Sterol regulatory element binding protein 1 (SREBP-1) is a lipogenic transcription factor of the basic helix-loop-helix… (More)
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Highly Cited
2000
Highly Cited
2000
Leptin, troglitazone, and the expression of sterol regulatory element binding proteins in liver and pancreatic islets.
Overaccumulation of lipids in nonadipose tissues of obese rodents may lead to lipotoxic complications such as diabetes. To assess… (More)
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2000
2000
Sterol regulatory element-binding protein-1 participates in the regulation of fatty acid synthase expression in colorectal neoplasia.
Endogenous fatty acid synthesis has been observed in certain rapidly proliferating normal and neoplastic tissues. Sterol… (More)
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Highly Cited
1997
Highly Cited
1997
Cholesterol feeding reduces nuclear forms of sterol regulatory element binding proteins in hamster liver.
Cholesterol feeding reduces the mRNAs encoding multiple enzymes in the cholesterol biosynthetic pathway and the low density… (More)
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Highly Cited
1995
Highly Cited
1995
Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13.
Sterol regulatory element binding protein-1 (SREBP1) and SREBP2 are structurally related proteins that control cholesterol… (More)
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Highly Cited
1993
Highly Cited
1993
SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element.
We report the cDNA cloning of SREBP-2, the second member of a family of basic-helix-loop-helix-leucine zipper (bHLH-Zip… (More)
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Highly Cited
1993
Highly Cited
1993
SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene
Sterol regulatory element 1 (SRE-1), a decamer (5'-ATC-ACCCCAC-3') flanking the low density lipoprotein (LDL) receptor gene… (More)
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Highly Cited
1993
Highly Cited
1993
Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. I. Identification of the protein and delineation of its target nucleotide sequence.
The current paper reports the identification of a protein in rat liver nuclei that binds to the sterol regulatory element (SRE-1… (More)
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