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Sterol Regulatory Element Binding Protein 1

Known as: SREBP1 Protein, SREBF1, Sterol Regulatory Element Binding Protein 1 [Chemical/Ingredient] 
A sterol regulatory element binding protein that regulates expression of GENES involved in FATTY ACIDS metabolism and LIPOGENESIS. Two major isoforms… 
National Institutes of Health

Related topics

Related topics

23 relations
Basic Helix-Loop-Helix Transcription FactorsCaspase Cascade PathwayCell NucleusGenes, Regulator

Narrower (2)

Sterol Regulatory Element Binding Protein 1aSterol Regulatory Element Binding Protein 1c

Papers overview

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Highly Cited
2011
Highly Cited
2011
Inhibition of miR-33a/b in non-human primates raises plasma HDL and reduces VLDL triglycerides
Cardiovascular disease remains the leading cause of mortality in westernized countries, despite optimum medical therapy to reduce… 
Highly Cited
2011
Highly Cited
2011
Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation.
Th17 cells are a subset of CD4+ T cells with an important role in clearing certain bacterial and fungal pathogens. However, they… 
Highly Cited
2010
Highly Cited
2010
Sterol regulatory element binding protein and dietary lipid regulation of fatty acid synthesis in the mammary epithelium.
The lactating mammary gland synthesizes large amounts of triglyceride from fatty acids derived from the blood and from de novo… 
Highly Cited
2008
Highly Cited
2008
Physiology.. Mice
  • 2008
  • Corpus ID: 8188
Highly Cited
2008
Highly Cited
2008
Sterol regulatory element binding protein 1 interacts with pregnane X receptor and constitutive androstane receptor and represses their target genes
Objective Sterol regulatory element binding protein 1 (SREBP-1) is a lipogenic transcription factor of the basic helix-loop-helix… 
Highly Cited
2000
Highly Cited
2000
Sterol regulatory element-binding protein-1 participates in the regulation of fatty acid synthase expression in colorectal neoplasia.
Endogenous fatty acid synthesis has been observed in certain rapidly proliferating normal and neoplastic tissues. Sterol… 
Highly Cited
1998
Highly Cited
1998
Oleate Potentiates Oxysterol Inhibition of Transcription from Sterol Regulatory Element-1-regulated Promoters and Maturation of Sterol Regulatory Element-binding Proteins*
Activation of genes containing SRE-1 (sterol regulatory element1) sequences is known to be under the regulation of sterols… 
Highly Cited
1997
Highly Cited
1997
Cholesterol feeding reduces nuclear forms of sterol regulatory element binding proteins in hamster liver.
Cholesterol feeding reduces the mRNAs encoding multiple enzymes in the cholesterol biosynthetic pathway and the low density… 
Highly Cited
1997
Highly Cited
1997
Structure of the human gene encoding sterol regulatory element binding protein 2 (SREBF2).
Sterol-regulatory element binding protein (SREBP) 1 and SREBP2 are ubiquitously expressed transcription factors that play key… 
Highly Cited
1997
Highly Cited
1997
Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene.
The synthesis of cholesterol and its uptake from plasma LDL are regulated by two membrane-bound transcription factors, designated… 
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