FAQ

Sterol Regulatory Element Binding Protein 1a

Known as: SREBP 1a, SREBP-1a 
SREBP1-A is an isoform of sterol regulatory element binding protein 1 that is a potent activator of GENETIC TRANSCRIPTION. It is the predominant form… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1993-2018
05101519932018

Related topics

Related topics

1 relation

Broader (1)

Sterol Regulatory Element Binding Protein 1

Related mentions per year

Related mentions per year

1993-2018
1990200020102020
Sterol Regulatory Element Binding Protein 1a
Sterol Regulatory Element Binding Protein 1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2003
Highly Cited
2003
Overexpression of sterol regulatory element-binding protein-1a in mouse adipose tissue produces adipocyte hypertrophy, increased fatty acid secretion, and fatty liver.
Sterol regulatory element-binding proteins (SREBPs) are a family of membrane-bound transcription factors that regulate… (More)
  • figure 1
  • table I
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c.
Two treatments, fasting/refeeding and administration of liver X receptor (LXR) agonists, elevate the mRNA for sterol regulatory… (More)
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta.
The liver X receptors (LXRs) are members of the nuclear hormone receptor superfamily that are bound and activated by oxysterols… (More)
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Fish oil feeding decreases mature sterol regulatory element-binding protein 1 (SREBP-1) by down-regulation of SREBP-1c mRNA in mouse liver. A possible mechanism for down-regulation of lipogenic…
Dietary fish oil induces hepatic peroxisomal and microsomal fatty acid oxidation by peroxisome proliferator-activator receptor… (More)
Is this relevant?
Highly Cited
1998
Highly Cited
1998
Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.
We produced transgenic mice that express a dominant-positive truncated form of sterol regulatory element-binding protein-2 (SREBP… (More)
  • figure 1
  • table I
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
1998
1998
Co-crystal structure of sterol regulatory element binding protein 1a at 2.3 A resolution.
BACKGROUND The sterol regulatory element binding proteins (SREBPs) are helix-loop-helix transcriptional activators that control… (More)
Is this relevant?
Highly Cited
1997
Highly Cited
1997
Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.
We have produced transgenic mice whose livers express a dominant positive NH2-terminal fragment of sterol regulatory element… (More)
  • figure 1
  • figure 2
  • table I
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
1997
Highly Cited
1997
Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells.
The 5' end of the mRNA-encoding sterol regulatory element binding protein-1 (SREBP-1) exists in two forms, designated 1a and 1c… (More)
  • table I
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
1996
Highly Cited
1996
Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.
The NH2-terminal domain of sterol-regulatory element binding protein-1a (SREBP-1a) activates transcription of genes encoding… (More)
  • table I
  • table II
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
1993
Highly Cited
1993
SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element.
We report the cDNA cloning of SREBP-2, the second member of a family of basic-helix-loop-helix-leucine zipper (bHLH-Zip… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?