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Sterol Regulatory Element Binding Protein 1a

Known as: SREBP 1a, SREBP-1a 
SREBP1-A is an isoform of sterol regulatory element binding protein 1 that is a potent activator of GENETIC TRANSCRIPTION. It is the predominant form… Expand
National Institutes of Health

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Sterol Regulatory Element Binding Protein 1

Papers overview

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Highly Cited
2011
Highly Cited
2011
Linking lipid metabolism to the innate immune response in macrophages through sterol regulatory element binding protein-1a.
We show that mice with a targeted deficiency in the gene encoding the lipogenic transcription factor SREBP-1a are resistant to… Expand
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Review
2004
Review
2004
SREBP transcription factors: master regulators of lipid homeostasis.
Sterol regulatory element binding proteins (SREBPs) are a family of transcription factors that regulate lipid homeostasis by… Expand
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Highly Cited
2004
Highly Cited
2004
Dysregulation of sterol response element-binding proteins and downstream effectors in prostate cancer during progression to androgen independence.
Androgen ablation, the most common therapeutic treatment used for advanced prostate cancer, triggers the apoptotic regression of… Expand
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Highly Cited
2003
Highly Cited
2003
Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes.
The synthesis of fatty acids and cholesterol, the building blocks of membranes, is regulated by three membrane-bound… Expand
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Highly Cited
2003
Highly Cited
2003
Overexpression of sterol regulatory element-binding protein-1a in mouse adipose tissue produces adipocyte hypertrophy, increased fatty acid secretion, and fatty liver.
Sterol regulatory element-binding proteins (SREBPs) are a family of membrane-bound transcription factors that regulate… Expand
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Highly Cited
2002
Highly Cited
2002
Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c.
Two treatments, fasting/refeeding and administration of liver X receptor (LXR) agonists, elevate the mRNA for sterol regulatory… Expand
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Review
2002
Review
2002
Sterol regulatory element-binding protein family as global regulators of lipid synthetic genes in energy metabolism.
Sterol regulatory element-binding proteins (SREBPs) have been established as lipid synthetic transcription factors for… Expand
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Highly Cited
2001
Highly Cited
2001
Polyunsaturated fatty acids suppress hepatic sterol regulatory element-binding protein-1 expression by accelerating transcript decay.
The reduction in hepatic abundance of sterol regulatory element binding protein-1 (SREBP-1) mRNA and protein associated with the… Expand
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Highly Cited
1997
Highly Cited
1997
Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.
We have produced transgenic mice whose livers express a dominant positive NH2-terminal fragment of sterol regulatory element… Expand
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Highly Cited
1993
Highly Cited
1993
SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element.
We report the cDNA cloning of SREBP-2, the second member of a family of basic-helix-loop-helix-leucine zipper (bHLH-Zip… Expand
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