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Sterol Regulatory Element Binding Protein 1a
Known as:
SREBP 1a
, SREBP-1a
SREBP1-A is an isoform of sterol regulatory element binding protein 1 that is a potent activator of GENETIC TRANSCRIPTION. It is the predominant form…
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National Institutes of Health
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Sterol Regulatory Element Binding Protein 1
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Linking lipid metabolism to the innate immune response in macrophages through sterol regulatory element binding protein-1a.
S. Im
,
Leyla Yousef
,
+5 authors
T. Osborne
Cell metabolism
2011
Corpus ID: 206837845
Review
2004
Review
2004
SREBP transcription factors: master regulators of lipid homeostasis.
D. Eberlé
,
B. Hegarty
,
P. Bossard
,
P. Ferré
,
F. Foufelle
Biochimie
2004
Corpus ID: 40559213
Highly Cited
2003
Highly Cited
2003
Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes
J. Horton
,
N. Shah
,
+4 authors
J. Goldstein
Proceedings of the National Academy of Sciences…
2003
Corpus ID: 1803524
The synthesis of fatty acids and cholesterol, the building blocks of membranes, is regulated by three membrane-bound…
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Highly Cited
2003
Highly Cited
2003
Overexpression of Sterol Regulatory Element-binding Protein-1a in Mouse Adipose Tissue Produces Adipocyte Hypertrophy, Increased Fatty Acid Secretion, and Fatty Liver*
J. Horton
,
I. Shimomura
,
S. Ikemoto
,
Y. Bashmakov
,
R. Hammer
Journal of Biological Chemistry
2003
Corpus ID: 25043969
Sterol regulatory element-binding proteins (SREBPs) are a family of membrane-bound transcription factors that regulate…
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Highly Cited
2002
Highly Cited
2002
Diminished Hepatic Response to Fasting/Refeeding and Liver X Receptor Agonists in Mice with Selective Deficiency of Sterol Regulatory Element-binding Protein-1c*
G. Liang
,
Jian Yang
,
J. Horton
,
R. Hammer
,
J. Goldstein
,
Michael S. Brown
The Journal of Biological Chemistry
2002
Corpus ID: 31740184
Two treatments, fasting/refeeding and administration of liver X receptor (LXR) agonists, elevate the mRNA for sterol regulatory…
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Highly Cited
2001
Highly Cited
2001
Polyunsaturated Fatty Acids Suppress Hepatic Sterol Regulatory Element-binding Protein-1 Expression by Accelerating Transcript Decay*
Jing Xu
,
M. Téran-García
,
Jung H. Y. Park
,
Manabu T. Nakamura
,
S. Clarke
The Journal of Biological Chemistry
2001
Corpus ID: 38447595
The reduction in hepatic abundance ofsterol regulatory element binding protein-1(SREBP-1) mRNA and protein associated with the…
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Highly Cited
2000
Highly Cited
2000
Sterol regulatory element binding proteins (SREBP)-1a and SREBP-2 are linked to the MAP-kinase cascade.
J. Kotzka
,
D. Müller-Wieland
,
+5 authors
W. Krone
Journal of lipid research
2000
Corpus ID: 20701604
The classic sterol regulatory cis element (sre-1) in the LDL receptor promoter mediates sterol regulatory element binding protein…
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Highly Cited
1997
Highly Cited
1997
Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.
H. Shimano
,
J. Horton
,
I. Shimomura
,
R. Hammer
,
M. Brown
,
J. Goldstein
The Journal of clinical investigation
1997
Corpus ID: 3072853
We have produced transgenic mice whose livers express a dominant positive NH2-terminal fragment of sterol regulatory element…
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Highly Cited
1996
Highly Cited
1996
Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.
H. Shimano
,
J. Horton
,
R. Hammer
,
I. Shimomura
,
M. Brown
,
J. Goldstein
The Journal of clinical investigation
1996
Corpus ID: 30196429
The NH2-terminal domain of sterol-regulatory element binding protein-1a (SREBP-1a) activates transcription of genes encoding…
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Highly Cited
1993
Highly Cited
1993
SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element.
X. Hua
,
C. Yokoyama
,
+4 authors
X. Wang
Proceedings of the National Academy of Sciences…
1993
Corpus ID: 12768261
We report the cDNA cloning of SREBP-2, the second member of a family of basic-helix-loop-helix-leucine zipper (bHLH-Zip…
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