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Sterol Regulatory Element Binding Protein 1a

Known as: SREBP 1a, SREBP-1a 
SREBP1-A is an isoform of sterol regulatory element binding protein 1 that is a potent activator of GENETIC TRANSCRIPTION. It is the predominant form… Expand
National Institutes of Health

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Sterol Regulatory Element Binding Protein 1

Papers overview

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Highly Cited
2011
Highly Cited
2011
Linking lipid metabolism to the innate immune response in macrophages through sterol regulatory element binding protein-1a.
We show that mice with a targeted deficiency in the gene encoding the lipogenic transcription factor SREBP-1a are resistant to… Expand
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Review
2004
Review
2004
SREBP transcription factors: master regulators of lipid homeostasis.
Sterol regulatory element binding proteins (SREBPs) are a family of transcription factors that regulate lipid homeostasis by… Expand
Highly Cited
2003
Highly Cited
2003
Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes
The synthesis of fatty acids and cholesterol, the building blocks of membranes, is regulated by three membrane-bound… Expand
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Highly Cited
2003
Highly Cited
2003
Overexpression of Sterol Regulatory Element-binding Protein-1a in Mouse Adipose Tissue Produces Adipocyte Hypertrophy, Increased Fatty Acid Secretion, and Fatty Liver*
Sterol regulatory element-binding proteins (SREBPs) are a family of membrane-bound transcription factors that regulate… Expand
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Highly Cited
2002
Highly Cited
2002
Diminished Hepatic Response to Fasting/Refeeding and Liver X Receptor Agonists in Mice with Selective Deficiency of Sterol Regulatory Element-binding Protein-1c*
Two treatments, fasting/refeeding and administration of liver X receptor (LXR) agonists, elevate the mRNA for sterol regulatory… Expand
Highly Cited
2001
Highly Cited
2001
Polyunsaturated Fatty Acids Suppress Hepatic Sterol Regulatory Element-binding Protein-1 Expression by Accelerating Transcript Decay*
The reduction in hepatic abundance ofsterol regulatory element binding protein-1(SREBP-1) mRNA and protein associated with the… Expand
Highly Cited
2000
Highly Cited
2000
Sterol regulatory element binding proteins (SREBP)-1a and SREBP-2 are linked to the MAP-kinase cascade.
The classic sterol regulatory cis element (sre-1) in the LDL receptor promoter mediates sterol regulatory element binding protein… Expand
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Highly Cited
1997
Highly Cited
1997
Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.
We have produced transgenic mice whose livers express a dominant positive NH2-terminal fragment of sterol regulatory element… Expand
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Highly Cited
1996
Highly Cited
1996
Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.
The NH2-terminal domain of sterol-regulatory element binding protein-1a (SREBP-1a) activates transcription of genes encoding… Expand
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Highly Cited
1993
Highly Cited
1993
SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element.
We report the cDNA cloning of SREBP-2, the second member of a family of basic-helix-loop-helix-leucine zipper (bHLH-Zip… Expand
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