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Steroid 21-Monooxygenase

Known as: Cytochrome P 450 CYP21, hydroxylase 21, 21-hydroxylase 
An adrenal microsomal cytochrome P450 enzyme that catalyzes the 21-hydroxylation of steroids in the presence of molecular oxygen and NADPH… 
National Institutes of Health

Related topics

Related topics

13 relations
21-Hydroxylase Ab:ACnc:Pt:Ser:QnCYP21A2 geneCongenital adrenal hyperplasiaIn Blood

Narrower (2)

CYP21A2 protein, humanCYP2C5 protein, Oryctolagus cuniculus

Papers overview

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Review
2008
Review
2008
Sexual Orientation in Women with Classical or Non-classical Congenital Adrenal Hyperplasia as a Function of Degree of Prenatal Androgen Excess
Abstract46,XX individuals with classical congenital adrenal hyperplasia (CAH) due to deficiency of the enzyme, 21-hydroxylase… 
Highly Cited
2004
Highly Cited
2004
Prevalence and clinical associations of 10 defined autoantibodies in autoimmune polyendocrine syndrome type I.
The prevalence of autoantibodies against nine intracellular enzyme autoantigens, namely 21-hydroxylase, side-chain cleavage… 
Highly Cited
2003
Highly Cited
2003
Glucocorticoid-induced increase in lymphocytic FKBP51 messenger ribonucleic acid expression: a potential marker for glucocorticoid sensitivity, potency, and bioavailability.
To reduce the side effects of corticosteroid treatment, the administered dose of glucocorticoids (GCs) should be kept to a… 
Highly Cited
1999
Highly Cited
1999
Screening for 21-hydroxylase-deficient nonclassic adrenal hyperplasia among hyperandrogenic women: a prospective study.
Highly Cited
1993
Highly Cited
1993
Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression.
The cytochrome P450 steroid hydroxylases are coordinately regulated by steroidogenic factor 1 (SF-1), a protein expressed… 
Highly Cited
1992
Highly Cited
1992
Steroidogenic factor I, a key regulator of steroidogenic enzyme expression, is the mouse homolog of fushi tarazu-factor I.
We proposed that a cell-selective regulatory protein coordinately regulates the expression of three enzymes that are required for… 
Highly Cited
1991
Highly Cited
1991
A shared promoter element regulates the expression of three steroidogenic enzymes.
The adrenal cortex of the mouse coordinately expresses three cytochrome P450 enzymes that are required for the biosynthesis of… 
Highly Cited
1988
Highly Cited
1988
Worldwide experience in newborn screening for classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency.
Highly Cited
1988
Highly Cited
1988
Aberrant splicing and missense mutations cause steroid 21-hydroxylase [P-450(C21)] deficiency in humans: possible gene conversion products.
Four steroid 21-hydroxylase B [P-450(C21)B] genes (designated P.7, P.10-1, P.10-2, and P.3) from three P-450(C21)-deficient… 
Highly Cited
1984
Highly Cited
1984
HLA-linked congenital adrenal hyperplasia results from a defective gene encoding a cytochrome P-450 specific for steroid 21-hydroxylation.
We have determined the molecular genetic basis of congenital adrenal hyperplasia due to 21-hydroxylase (21-OHase) deficiency… 
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