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Positions statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an Androgen Excess Society guideline.
TLDR
It is the view of the AES Task Force on the Phenotype of PCOS that there should be acceptance of the original 1990 National Institutes of Health criteria with some modifications, taking into consideration the concerns expressed in the proceedings of the 2003 Rotterdam conference. Expand
The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report.
TLDR
It is the view of the AE-PCOS Society Task Force that PCOS should be defined by the presence of hyperandrogenism, ovarian dysfunction, and/or polycystic ovaries, and the exclusion of related disorders. Expand
Ultrasound assessment of the polycystic ovary: international consensus definitions.
TLDR
Evidence for the current ultrasound definition of the polycystic ovary is outlined and a woman having PCO in the absence of an ovulation disorder or hyperandrogenism ('asymptomatic PCO') should not be considered as having PCOS, until more is known about this situation. Expand
Elevated serum level of anti-mullerian hormone in patients with polycystic ovary syndrome: relationship to the ovarian follicle excess and to the follicular arrest.
TLDR
The data suggest that the increase of AMH serum level in PCOS is the consequence of the androgen-induced excess in small antral FN and that each follicle produces a normal amount ofAMH. Expand
The physiology and clinical utility of anti-Mullerian hormone in women.
TLDR
There is a linear relationship between AMH and oocyte yield after ovarian stimulation, which is of value in predicting ovarian hyperstimulation, and the submerged part of the iceberg of follicle growth, i.e. the intrinsic, so-called 'acyclic' ovarian activity is measured. Expand
Diagnosis of polycystic ovary syndrome (PCOS): revisiting the threshold values of follicle count on ultrasound and of the serum AMH level for the definition of polycystic ovaries.
TLDR
For the definition of PCOM, the former threshold of >12 for FN is no longer valid and a serum AMH >35 pmol/l appears to be more sensitive and specific than a FN >19 and should be included in the current diagnostic classifications for PCOS. Expand
Serum anti-Mullerian hormone as a surrogate for antral follicle count for definition of the polycystic ovary syndrome.
TLDR
The serum AMH level is an accurate marker of the ovarian early antral follicle number and offers a good diagnostic potency, and could be used instead of the follicle count as a diagnostic criterion and incorporated as such in the Rotterdam definition of PCOS. Expand
Mutations and sequence variants in GDF9 and BMP15 in patients with premature ovarian failure.
TLDR
It is proposed that although mutations in BMP15 and GDF9 are not a major cause of ovarian insufficiency, they may be involved in POF. Expand
Polycystic ovary syndrome
TLDR
The diagnostic traits of polycystic ovary syndrome are hyperandrogenism, chronic anovulation, and poly Cystic ovaries, after exclusion of other conditions that cause these same features. Expand
The follicular excess in polycystic ovaries, due to intra-ovarian hyperandrogenism, may be the main culprit for the follicular arrest.
TLDR
The hypothesis that the follicular problem in PCOS is 2-fold, but with the two abnormalities being linked, is proposed, whereby the intra-ovarian hyperandrogenism may promote early follicular growth, leading to a 2-5 mm follicle excess. Expand
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