CYP21A2 gene

Known as: P450C21, CYTOCHROME P450, SUBFAMILY XXI, CYTOCHROME P450, FAMILY 21, SUBFAMILY A, POLYPEPTIDE 2 
This gene plays a role in steroid metabolism.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1977-2018
0102019772018

Papers overview

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Highly Cited
2004
Highly Cited
2004
BACKGROUND Congenital adrenal hyperplasia with apparent combined P450C17 and P450C21 deficiency is associated with accumulation… (More)
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Highly Cited
1999
Highly Cited
1999
The frequent variations of human complement component C4 gene size and gene numbers, plus the extensive polymorphism of the… (More)
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1998
1998
The purpose of this study was to evaluate the effects of acute (a single injection) and chronic stimulation (twice daily… (More)
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Highly Cited
1993
Highly Cited
1993
Lesions in the gene encoding steroid 21-hydroxylase (CYP21) result in defective adrenal steroid synthesis; the severe forms are… (More)
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1991
1991
The mild nonclassic form of steroid 21-hydroxylase deficiency is one of the most common autosomal recessive disorders in humans… (More)
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Highly Cited
1991
Highly Cited
1991
We have previously demonstrated that tumor necrosis factor alpha (TNF-alpha), a multifunctional cytokine mainly produced by… (More)
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Highly Cited
1988
Highly Cited
1988
Steroid 21-hydroxylase deficiency is caused by mutations in the CYP21B gene. This gene and a highly homologous pseudogene, CYP21A… (More)
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1988
1988
Steroid 21-hydroxylase deficiency is the most common cause of congenital adrenal hyperplasia. It results from a deficiency in a… (More)
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Highly Cited
1987
Highly Cited
1987
P450c17 is the single enzyme mediating both 17 alpha-hydroxylase (steroid 17 alpha-monooxygenase, EC 1.14.99.9) and 17,20 lyase… (More)
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Highly Cited
1987
Highly Cited
1987
P450c17 is a single cytochrome P450 enzyme mediating both 17 alpha-hydroxylase and 17,20 lyase activities in the biosynthesis of… (More)
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