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Common epicardial origin of coronary vascular smooth muscle, perivascular fibroblasts, and intermyocardial fibroblasts in the avian heart.
Previous studies have shown that during avian heart development, epicardial and coronary vascular smooth muscle precursors are derived from the proepicardium, a derivative of the developing liver.Expand
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Rapid Quantification of Mutant Fitness in Diverse Bacteria by Sequencing Randomly Bar-Coded Transposons
ABSTRACT Transposon mutagenesis with next-generation sequencing (TnSeq) is a powerful approach to annotate gene function in bacteria, but existing protocols for TnSeq require laborious preparation ofExpand
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Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome
Noonan syndrome is a developmental disorder characterized by short stature, facial dysmorphia, congenital heart defects and skeletal anomalies. Increased RAS-mitogen-activated protein kinase (MAPK)Expand
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Tenascin–X deficiency is associated with Ehlers–Danlos syndrome
The tenascins are a family of large extracellular matrix proteins with at least three members: tenascin-X (TNX)1–3, tenascin-C (TNC, or cytotactin)4–6 and tenascin-R (TN-R, or restrict in)7,8.Expand
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Positive and negative regulation of epicardial-mesenchymal transformation during avian heart development.
In the developing heart, the epicardium is essential for coronary vasculogenesis as it provides precursor cells that become coronary vascular smooth muscle and perivascular fibroblasts. TheseExpand
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ChIP-Seq identification of weakly conserved heart enhancers
Accurate control of tissue-specific gene expression plays a pivotal role in heart development, but few cardiac transcriptional enhancers have thus far been identified. Extreme noncoding-sequenceExpand
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Tenascin-X deficiency mimics Ehlers-Danlos syndrome in mice through alteration of collagen deposition
Tenascin-X is a large extracellular matrix protein of unknown function. Tenascin-X deficiency in humans is associated with Ehlers–Danlos syndrome, a generalized connective tissue disorder resultingExpand
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The Airborne Metagenome in an Indoor Urban Environment
The indoor atmosphere is an ecological unit that impacts on public health. To investigate the composition of organisms in this space, we applied culture-independent approaches to microbes harvestedExpand
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Genomic Characterization of Methanomicrobiales Reveals Three Classes of Methanogens
Background Methanomicrobiales is the least studied order of methanogens. While these organisms appear to be more closely related to the Methanosarcinales in ribosomal-based phylogenetic analyses,Expand
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The Ehlers-Danlos syndrome: on beyond collagens.
  • J. Mao, J. Bristow
  • Biology, Medicine
  • The Journal of clinical investigation
  • 1 May 2001
The Ehlers-Danlos syndrome (EDS) is a clinically and genetically heterogeneous connective tissue disorder affecting as many as 1 in 5,000 individuals (1). EDS is characterized in its most common formExpand
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