Glucocorticoid-induced increase in lymphocytic FKBP51 messenger ribonucleic acid expression: a potential marker for glucocorticoid sensitivity, potency, and bioavailability.

@article{Vermeer2003GlucocorticoidinducedII,
  title={Glucocorticoid-induced increase in lymphocytic FKBP51 messenger ribonucleic acid expression: a potential marker for glucocorticoid sensitivity, potency, and bioavailability.},
  author={Harry Vermeer and Brenda I Hendriks-Stegeman and Bart van der Burg and Sylvia C van Buul-Offers and Maarten Jansen},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2003},
  volume={88 1},
  pages={
          277-84
        }
}
To reduce the side effects of corticosteroid treatment, the administered dose of glucocorticoids (GCs) should be kept to a minimum while preserving therapeutically needed intracellular levels. Currently available assays to determine individual sensitivity to GCs are either imprecise or based on inhibition by GCs of lymphocyte proliferation following stimulation with phytohemagglutinin or other mitogens, which may influence the GC signal transduction pathway. Using the human lymphoblastoid cell… CONTINUE READING

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