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Stat3 protein

Known as: Acute-Phase Response Factor, Signal Transducer and Activator of Transcription 3, IL6 Response Factor 
A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-6 family members. STAT3 is constitutively… 
National Institutes of Health

Related topics

Related topics

36 relations
Adipocytokine Signaling PathwayCrohn DiseaseDNA-Binding ProteinsEGF Signaling Pathway

Narrower (2)

STAT3a Transcription FactorSTAT3b Transcription Factor

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Fragment-based drug design and drug repositioning using multiple ligand simultaneous docking (MLSD): identifying celecoxib and template compounds as novel inhibitors of signal transducer and…
We describe a novel method of drug discovery using MLSD and drug repositioning, with cancer target STAT3 being used as a test… 
Highly Cited
2005
Highly Cited
2005
In vivo antitumor efficacy of STAT3 blockade using a transcription factor decoy approach: implications for cancer therapy
The development of more effective prevention and treatment strategies for solid tumors is limited by an incomplete understanding… 
Highly Cited
2004
Highly Cited
2004
A high-throughput fluorescence polarization assay for signal transducer and activator of transcription 3.
Highly Cited
2003
Highly Cited
2003
Identification of a high-affinity phosphopeptide inhibitor of Stat3.
Highly Cited
2001
Highly Cited
2001
Role of STAT3 and PI 3-Kinase/Akt in Mediating the Survival Actions of Cytokines on Sensory Neurons
The binding of cytokines to the gp130 receptor activates the STAT3, MEK/MAPK, and PI3K/Akt signalling pathways. To assess the… 
Highly Cited
2001
Highly Cited
2001
EGFR dependent expression of STAT3 (but not STAT1) in breast cancer.
STAT proteins constitute a family of transcription factors whose activation by cytokine and non-cytokine receptors leads to… 
Highly Cited
2000
Highly Cited
2000
Androgen and estrogen receptors in splenic T lymphocytes: effects of flutamide and trauma-hemorrhage.
The endogenous sex steroids, testosterone and beta-estradiol, play a major role in inflammatory processes. They regulate several… 
Highly Cited
1996
Highly Cited
1996
Steel factor induces serine phosphorylation of Stat3 in human growth factor-dependent myeloid cell lines.
Steel factor (SLF) acts synergistically with various hematopoietic growth factors that use the Jak-Stat pathways in vivo and in… 
Highly Cited
1995
Highly Cited
1995
Use of 2,3-naphthalenedicarboxaldehyde derivatization for single-cell analysis of glutathione by capillary electrophoresis and histochemical localization by fluorescence microscopy.
We report that 2,3-naphthalenedicarboxaldehyde reacts rapidly with glutathione and its precursor, gamma-glutamylcysteine, to form… 
Highly Cited
1995
Highly Cited
1995
Activation of Acute Phase Response Factor (APRF)/Stat3 Transcription Factor by Growth Hormone (*)
The mechanisms by which the binding of growth hormone (GH) to its cell surface receptor elicits changes in gene transcription are… 
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