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Sphingosine 1-Phosphate Receptor 2

Known as: Sphingosine-1-Phosphate Receptor 2, Sphingosine 1-Phosphate Receptor EDG-5, Endothelial Differentiation G-Protein Coupled Receptor 5 
Sphingosine 1-phosphate receptor 2 (353 aa, ~39 kDa) is encoded by the human S1PR2 gene. This protein is involved in transcriptional activation, cell… Expand
National Institutes of Health

Related topics

Related topics

15 relations
Cytoskeletal ModelingG Protein-Coupled Receptor GenesG Protein-Coupled Receptor SignalingIntegral Membrane Proteins
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Bile Acid-Mediated Sphingosine-1-Phosphate Receptor 2 Signaling Promotes Neuroinflammation during Hepatic Encephalopathy in Mice
Hepatic encephalopathy (HE) is a neuropsychiatric complication that occurs due to deteriorating hepatic function and this… Expand
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Highly Cited
2015
Highly Cited
2015
Conjugated bile acid-activated S1P receptor 2 is a key regulator of sphingosine kinase 2 and hepatic gene expression.
UNLABELLED Bile acids are important hormones during the feed/fast cycle, allowing the liver to coordinately regulate nutrient… Expand
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2015
2015
Taurocholate Induces Cyclooxygenase-2 Expression via the Sphingosine 1-phosphate Receptor 2 in a Human Cholangiocarcinoma Cell Line*
Background: Cyclooxygenase-2 (COX-2) and sphingosine 1-phosphate receptor 2 (S1PR2) are highly expressed in human… Expand
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Highly Cited
2014
Highly Cited
2014
Conjugated bile acids promote cholangiocarcinoma cell invasive growth through activation of sphingosine 1-phosphate receptor 2
Cholangiocarcinoma (CCA) is an often fatal primary malignancy of the intra- and extrahepatic biliary tract that is commonly… Expand
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Highly Cited
2014
Highly Cited
2014
The Sphingolipid Receptor S1PR2 Is a Receptor for Nogo-A Repressing Synaptic Plasticity
This study identifies a GPCR, S1PR2, as a receptor for the Nogo-A-Δ20 domain of the membrane protein Nogo-A, which inhibits… Expand
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Highly Cited
2013
Highly Cited
2013
Critical role of sphingosine-1-phosphate receptor 2 (S1PR2) in acute vascular inflammation.
The endothelium, as the interface between blood and all tissues, plays a critical role in inflammation. Sphingosine-1-phosphate… Expand
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2013
2013
A sphingosine 1-phosphate receptor 2 selective allosteric agonist.
Molecular probe tool compounds for the Sphingosine 1-phosphate receptor 2 (S1PR2) are important for investigating the multiple… Expand
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Highly Cited
2012
Highly Cited
2012
Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes.
Bile acids have been shown to be important regulatory molecules for cells in the liver and gastrointestinal tract. They can… Expand
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2010
2010
Sphingosine 1-Phosphate Receptor 2 Signals Through Leukemia-Associated RhoGEF (LARG), to Promote Smooth Muscle Cell Differentiation
Objective—The goals of this study were to identify the signaling pathway by which sphingosine 1-phosphate (S1P) activates RhoA in… Expand
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Highly Cited
2010
Highly Cited
2010
Dihydrosphingosine 1-phosphate has a potent antifibrotic effect in scleroderma fibroblasts via normalization of phosphatase and tensin homolog levels.
OBJECTIVE Previous studies have revealed a phosphatase and tensin homolog (PTEN)-dependent interaction between the sphingolipid… Expand
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