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A randomized trial of protocol-based care for early septic shock.
BACKGROUND In a single-center study published more than a decade ago involving patients presenting to the emergency department with severe sepsis and septic shock, mortality was markedly lower amongExpand
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Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury
IntroductionAcute kidney injury (AKI) can evolve quickly and clinical measures of function often fail to detect AKI at a time when interventions are likely to provide benefit. Identifying earlyExpand
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Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial.
CONTEXT Goal-directed resuscitation for severe sepsis and septic shock has been reported to reduce mortality when applied in the emergency department. OBJECTIVE To test the hypothesis ofExpand
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Mortality in Emergency Department Sepsis (MEDS) score: A prospectively derived and validated clinical prediction rule*
ObjectivesOur objectives were a) to identify univariate correlates of death in emergency department patients at risk for infection; b) to perform multivariate analyses and identify independentExpand
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Serum lactate as a predictor of mortality in emergency department patients with infection.
STUDY OBJECTIVE Little is known about risk-stratification biomarkers in emergency department (ED) patients with suspected infection, and lactate is a biologically plausible candidate. We determineExpand
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Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality.
CONTEXT Laboratory investigations suggest that exposure to hyperoxia after resuscitation from cardiac arrest may worsen anoxic brain injury; however, clinical data are lacking. OBJECTIVE To testExpand
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Occult hypoperfusion and mortality in patients with suspected infection
ObjectiveTo determine, in the early stages of suspected clinically significant infection, the independent relationship of the presenting venous lactate level to 28-day in-hospitalExpand
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Implementation and outcomes of the Multiple Urgent Sepsis Therapies (MUST) protocol*
Objectives:To describe the effectiveness of a comprehensive, interdisciplinary sepsis treatment protocol with regard to both implementation and outcomes and to compare the mortality rates andExpand
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We sought to determine (a) if early lactate clearance is associated with improved survival in emergency department patients with severe sepsis and (b) the concordance between central venous oxygenExpand
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National estimates of severe sepsis in United States emergency departments
Objective:The emergency department (ED) often serves as the first site for the recognition and treatment of patients with suspected severe sepsis. However, few evaluations of the nationalExpand
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