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Spermine Synthase

Known as: Synthetase, Spermine, Spermine Synthetase, Synthase, Spermine 
An enzyme that catalyzes the transfer of the propylamine moiety from 5'-deoxy-5'-S-(3-methylthiopropylamine)sulfonium adenosine to spermidine in the… 
National Institutes of Health

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Related topics

8 relations
In BloodProcess of secretionSMS geneantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2007
Review
2007
Polyamines and neoplastic growth.
Studies over many years have suggested that increased polyamine synthesis may be necessary for neoplastic growth. This review… 
Highly Cited
2005
Highly Cited
2005
Potent modulation of intestinal tumorigenesis in Apcmin/+ mice by the polyamine catabolic enzyme spermidine/spermine N1-acetyltransferase.
Intracellular polyamine pools are homeostatically maintained by processes involving biosynthesis, catabolism, and transport… 
Review
2003
Review
2003
Transgenic mouse models for studies of the role of polyamines in normal, hypertrophic and neoplastic growth.
Transgenic mice expressing proteins altering polyamine levels in a tissue-specific manner have considerable promise for… 
Highly Cited
2003
Highly Cited
2003
Expression of SSAT, a novel biomarker of tubular cell damage, increases in kidney ischemia-reperfusion injury.
Ischemia-reperfusion injury (IRI) is the major cause of acute renal failure in native and allograft kidneys. Identifying the… 
Highly Cited
2001
Highly Cited
2001
Polyamine analogues inhibit the ubiquitination of spermidine/spermine N1-acetyltransferase and prevent its targeting to the proteasome for degradation.
Spermidine/spermine N(1)-acetyltransferase (SSAT), a key enzyme in mammalian polyamine catabolism, undergoes rapid turnover (half… 
Highly Cited
2000
Highly Cited
2000
Effects of Conditional Overexpression of Spermidine/Spermine N 1-Acetyltransferase on Polyamine Pool Dynamics, Cell Growth, and Sensitivity to Polyamine Analogs*
Acetylation of polyamines by spermidine/spermineN 1-acetyltransferase (SSAT) has been implicated in their degradation and/or… 
Highly Cited
1996
Highly Cited
1996
Structure and critical residues at the active site of spermidine/spermine-N1-acetyltransferase.
Spermidine/spermine-N1-acetyltransferase (SSAT) is a key enzyme in the degradation of polyamines. Alanine-scanning mutagenesis of… 
Highly Cited
1994
Highly Cited
1994
Antiproliferative properties of polyamine analogues: a structure-activity study.
A basis set of polyamine analogues was designed and synthesized. These compounds were used to initiate a systematic investigation… 
Highly Cited
1993
Highly Cited
1993
Synthesis and evaluation of unsymmetrically substituted polyamine analogues as modulators of human spermidine/spermine-N1-acetyltransferase (SSAT) and as potential antitumor agents.
Spermidine/spermine-N1-acetyltransferase (SSAT), the rate-limiting step in polyamine catabolism, is critical for the… 
Highly Cited
1991
Highly Cited
1991
Isolation and characterization of a cDNA clone that codes for human spermidine/spermine N1-acetyltransferase.
Spermidine/spermine N1-acetyltransferase (Spd/Spm acetyltransferase) is the rate-limiting enzyme in the catabolism of polyamines… 
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