Skip to search formSkip to main contentSkip to account menu

Spebrutinib

Known as: 2-Propenamide, N-(3-((5-fluoro-2-((4-(2-methoxyethoxy)phenyl)amino)-4-pyrimidinyl)amino)phenyl)- 
An orally bioavailable, selective inhibitor of Bruton's agammaglobulinemia tyrosine kinase (BTK), with potential antineoplastic activity. Upon… 
National Institutes of Health

Related topics

Related topics

3 relations
AVL-292Receptor Tyrosine Kinase Inhibition

Narrower (1)

CC-292

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Design, synthesis and biological evaluation of novel dithiocarbamate-substituted diphenylaminopyrimidine derivatives as BTK inhibitors.
2019
2019
JAK3 inhibitors based on thieno[3,2-d]pyrimidine scaffold: design, synthesis and bioactivity evaluation for the treatment of B-cell lymphoma.
2019
2019
Selective BTK inhibition improves bendamustine therapy response and normalizes immune effector functions in chronic lymphocytic leukemia
The Bruton's tyrosine kinase (BTK) inhibitor ibrutinib has been shown to be highly effective in patients with chronic lymphocytic… 
2019
2019
Naquotinib exerts antitumor activity in activated B-cell-like diffuse large B-cell lymphoma.
2019
2019
Synthesis, characterization, and biological evaluation of new spebrutinib analogues: potential candidates with enhanced activity and reduced toxicity profiles
Background: Cancer is regarded as an undoubtable major concern for both researchers and the general public because of its high… 
2017
2017
Structural optimization of diphenylpyrimidine derivatives (DPPYs) as potent Bruton's tyrosine kinase (BTK) inhibitors with improved activity toward B leukemia cell lines.
Review
2015
Review
2015
Emerging immunological drugs for chronic lymphocytic leukemia
Introduction: Over the last few years, several new immunological drugs, particularly monoclonal antibodies (mAbs… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)