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CC-292

Known as: Bruton's Tyrosine Kinase Inhibitor CC-292 
 
National Institutes of Health

Papers overview

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2017
2017
Ibrutinib is a first-in-class covalent inhibitor of Bruton tyrosine kinase (BTK) approved in the European Union and USA for the… Expand
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2017
2017
CC-292, a potent Bruton tyrosine kinase inhibitor, is under development for the treatment of B-cell malignancies. An analysis was… Expand
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2016
2016
B-cell receptor (BCR) signaling plays a key role in the pathogenesis of B-cell malignancies, mediating the survival and… Expand
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2016
2016
Additions of cysteine thiols to Michael acceptors underpin the mechanism of action of several covalent drugs (e.g., afatinib… Expand
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2015
2015
Ibrutinib, a first generation Btk inhibitor, is approved for the treatment of CLL and mantle cell lymphoma; known toxicities… Expand
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2014
2014
Bruton’s tyrosine kinase (Btk) modulates B-cell development and activation and has an important role in antibody production… Expand
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Highly Cited
2013
Highly Cited
2013
Targeted therapies that suppress B cell receptor (BCR) signaling have emerged as promising agents in autoimmune disease and B… Expand
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2013
2013
Introduction CC-292, an oral, highly selective, small-molecule irreversible-inhibitor of Btk is under investigation for the… Expand
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2013
2013
A member of the Tec family kinases, Bruton’s tyrosine kinase (Btk) modulates B-cell development and activation, and plays an… Expand
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2013
2013
Introduction The B-cell receptor (BCR) and its downstream effectors have emerged as important therapeutic targets in B-cell… Expand
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