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AVL-292

 
National Institutes of Health

Papers overview

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2016
2016
We have reported that a novel isoform of BTK (BTK-C) expressed in breast cancer protects these cells from apoptosis. In this… Expand
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2016
2016
Based on the pyrimidine skeleton of EGFRT790M inhibitors, a series of N,9-diphenyl-9H-purin-2-amine derivatives were identified… Expand
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2015
2015
Bruton's tyrosine kinase (Btk) is intricately involved in anti-apoptotic signaling pathways in cancer and in regulating innate… Expand
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2015
2015
Bruton's tyrosine kinase (BTK) is a non-receptor tyrosine kinase that has mainly been studied in haematopoietic cells. We have… Expand
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2012
2012
8032 Background: Btk supports activation, survival, and proliferation of malignant B cells in CLL and B-NHL. AVL-292 is an oral… Expand
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2012
2012
Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL Bruton's tyrosine kinase (Btk) plays a key role in… Expand
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2012
2012
On January 26, Celgene, of Summit, New Jersey, announced it would pay an initial $350 million for Avila Therapeutics. The… Expand
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2012
2012
Abstract 1822 The activation of Bruton9s tyrosine kinase (Btk), a member of the Tec family of tyrosine kinases regulates B-cell… Expand
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2011
2011
Abstract 3485 Targeted therapies that suppress B cell receptor (BCR) signaling have emerged as promising agents in the treatment… Expand
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