Spastic Paraplegia

Known as: Spastic Paraplegias, Paraplegia, Spastic, paralysis spinalis spastica 
Spasticity and weakness of the leg and hip muscles. [HPO:probinson]
National Institutes of Health

Papers overview

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Review
2012
Review
2012
Human voluntary movement is controlled by the pyramidal motor system, a long CNS pathway comprising corticospinal and lower motor… (More)
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Highly Cited
2010
Highly Cited
2010
Hereditary spastic paraplegias (HSPs; SPG1-45) are inherited neurological disorders characterized by lower extremity spastic… (More)
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Highly Cited
2008
Highly Cited
2008
Spastin, the most common locus for mutations in hereditary spastic paraplegias, and katanin are related microtubule-severing AAA… (More)
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Highly Cited
2005
Highly Cited
2005
AAA proteases comprise a conserved family of membrane bound ATP-dependent proteases that ensures the quality control of… (More)
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Highly Cited
2005
Highly Cited
2005
Pure hereditary spastic paraplegia is characterized by length-dependent degeneration of the distal ends of long axons. Mutations… (More)
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Highly Cited
2005
Highly Cited
2005
Hereditary spastic paraplegias (HSPs), a group of neurodegenerative disorders characterized by lower-extremity spasticity and… (More)
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Highly Cited
2004
Highly Cited
2004
Oligodendrocytes are critical for the development of the plasma membrane and cytoskeleton of the axon. In this paper, we show… (More)
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Highly Cited
2003
Highly Cited
2003
Mast syndrome is an autosomal recessive, complicated form of hereditary spastic paraplegia with dementia that is present at high… (More)
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Highly Cited
2002
Highly Cited
2002
Troyer syndrome (TRS) is an autosomal recessive complicated hereditary spastic paraplegia (HSP) that occurs with high frequency… (More)
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Highly Cited
1998
Highly Cited
1998
Hereditary spastic paraplegia (HSP) is characterized by progressive weakness and spasticity of the lower limbs due to… (More)
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