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CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination.
After central nervous system (CNS) demyelination-such as occurs during multiple sclerosis-there is often spontaneous regeneration of myelin sheaths, mainly by oligodendrocytes but also by SchwannExpand
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A Transgenic Rat Model of Charcot-Marie-Tooth Disease
Charcot-Marie-Tooth disease (CMT) is the most common inherited neuropathy in humans and has been associated with a partial duplication of chromosome 17 (CMT type 1A). We have generated a transgenicExpand
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Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity
Oligodendrocytes, the myelin-forming glial cells of the central nervous system, maintain long-term axonal integrity. However, the underlying support mechanisms are not understood. Here we identify aExpand
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Tamoxifen-inducible glia-specific Cre mice for somatic mutagenesis in oligodendrocytes and Schwann cells
Inducible transgenesis provides a valuable technique for the analysis of gene function in vivo. We report the generation and characterization of mouse lines carrying glia lineage-specific transgenesExpand
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Hypermyelination and demyelinating peripheral neuropathy in Pmp22-deficient mice
Peripheral myelin protein PMP22 has been suggested to have a role in peripheral nerve myelination and cell proliferation. Defects at the PMP22 locus are associated with peripheral neuropathies suchExpand
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Ganglioside-induced differentiation associated protein 1 is a regulator of the mitochondrial network
Mutations in GDAP1 lead to severe forms of the peripheral motor and sensory neuropathy, Charcot-Marie-Tooth disease (CMT), which is characterized by heterogeneous phenotypes, including pronouncedExpand
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Schwann Cell Precursors from Nerve Innervation Are a Cellular Origin of Melanocytes in Skin
Current opinion holds that pigment cells, melanocytes, are derived from neural crest cells produced at the dorsal neural tube and that migrate under the epidermis to populate all parts of the skin.Expand
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Survival and glial fate acquisition of neural crest cells are regulated by an interplay between the transcription factor Sox10 and extrinsic combinatorial signaling.
The transcription factor Sox10 is required for proper development of various neural crest-derived cell types. Several lineages including melanocytes, autonomic and enteric neurons, and all subtypesExpand
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Disease mechanisms in inherited neuropathies
Inherited neuropathies are caused by dominant or recessive mutations in genes that are expressed by neurons and/or Schwann cells. In demyelinating neuropathies, the deleterious effects originateExpand
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Instructive Role of Wnt/ß-Catenin in Sensory Fate Specification in Neural Crest Stem Cells
Wnt signaling has recently emerged as a key factor in controlling stem cell expansion. In contrast, we show here that Wnt/β-catenin signal activation in emigrating neural crest stem cells (NCSCs) hasExpand
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