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- Publications
- Influence
CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination.
- M. Zawadzka, L. Rivers, +12 authors R. Franklin
- Biology, Medicine
- Cell stem cell
- 4 June 2010
After central nervous system (CNS) demyelination-such as occurs during multiple sclerosis-there is often spontaneous regeneration of myelin sheaths, mainly by oligodendrocytes but also by Schwann… Expand
A Transgenic Rat Model of Charcot-Marie-Tooth Disease
- M. Sereda, I. Griffiths, +9 authors Klaus-Armin Nave
- Biology, Medicine
- Neuron
- 1 May 1996
Charcot-Marie-Tooth disease (CMT) is the most common inherited neuropathy in humans and has been associated with a partial duplication of chromosome 17 (CMT type 1A). We have generated a transgenic… Expand
Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity
- Ursula Fünfschilling, Lotti M Supplie, +16 authors K. Nave
- Biology, Medicine
- Nature
- 24 May 2012
Oligodendrocytes, the myelin-forming glial cells of the central nervous system, maintain long-term axonal integrity. However, the underlying support mechanisms are not understood. Here we identify a… Expand
Tamoxifen-inducible glia-specific Cre mice for somatic mutagenesis in oligodendrocytes and Schwann cells
- Dino P. Leone, S. Genoud, S. Atanasoski, R. Grausenburger, U. Suter
- Biology, Medicine
- Molecular and Cellular Neuroscience
- 1 April 2003
Inducible transgenesis provides a valuable technique for the analysis of gene function in vivo. We report the generation and characterization of mouse lines carrying glia lineage-specific transgenes… Expand
Hypermyelination and demyelinating peripheral neuropathy in Pmp22-deficient mice
- K. Adlkofer, R. Martini, A. Aguzzi, J. Zielasek, K. Toyka, U. Suter
- Biology, Medicine
- Nature Genetics
- 1 November 1995
Peripheral myelin protein PMP22 has been suggested to have a role in peripheral nerve myelination and cell proliferation. Defects at the PMP22 locus are associated with peripheral neuropathies such… Expand
Ganglioside-induced differentiation associated protein 1 is a regulator of the mitochondrial network
- A. Niemann, M. Ruegg, Veronica La Padula, A. Schenone, U. Suter
- Biology, Medicine
- The Journal of cell biology
- 26 September 2005
Mutations in GDAP1 lead to severe forms of the peripheral motor and sensory neuropathy, Charcot-Marie-Tooth disease (CMT), which is characterized by heterogeneous phenotypes, including pronounced… Expand
Schwann Cell Precursors from Nerve Innervation Are a Cellular Origin of Melanocytes in Skin
- I. Adameyko, F. Lallemend, +11 authors P. Ernfors
- Biology, Medicine
- Cell
- 16 October 2009
Current opinion holds that pigment cells, melanocytes, are derived from neural crest cells produced at the dorsal neural tube and that migrate under the epidermis to populate all parts of the skin.… Expand
Survival and glial fate acquisition of neural crest cells are regulated by an interplay between the transcription factor Sox10 and extrinsic combinatorial signaling.
- C. Paratore, D. Goerich, U. Suter, M. Wegner, L. Sommer
- Biology, Medicine
- Development
- 15 October 2001
The transcription factor Sox10 is required for proper development of various neural crest-derived cell types. Several lineages including melanocytes, autonomic and enteric neurons, and all subtypes… Expand
Disease mechanisms in inherited neuropathies
- U. Suter, S. Scherer
- Biology, Medicine
- Nature Reviews Neuroscience
- 1 September 2003
Inherited neuropathies are caused by dominant or recessive mutations in genes that are expressed by neurons and/or Schwann cells. In demyelinating neuropathies, the deleterious effects originate… Expand
Instructive Role of Wnt/ß-Catenin in Sensory Fate Specification in Neural Crest Stem Cells
- Hye-youn Lee, M. Kléber, +5 authors L. Sommer
- Biology, Medicine
- Science
- 13 February 2004
Wnt signaling has recently emerged as a key factor in controlling stem cell expansion. In contrast, we show here that Wnt/β-catenin signal activation in emigrating neural crest stem cells (NCSCs) has… Expand