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Sparteine
Known as:
Sparteine [Chemical/Ingredient]
, 7,14-Methano-2H,6H-dipyrido(1,2-a:1',2'-e)(1,5)diazocine, dodecahydro-, (7S-(7alpha,7aalpha,14alpha,14abeta))-
, Sparteine, (7S-(7alpha,7aalpha,14alpha,14abeta))-Isomer
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A quinolizidine alkaloid isolated from several FABACEAE including LUPINUS; SPARTIUM; and CYTISUS. It has been used as an oxytocic and an anti…
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National Institutes of Health
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Related topics
Related topics
27 relations
Narrower (15)
10,17-dioxosparteine
13-hydroxylupanine
17-oxosparteine
2-dehydrosparteine
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Broader (3)
Alkaloids
Anti-Arrhythmia Agents
Oxytocics
In Blood
Process of secretion
agonists
analogs & derivatives
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
Defective N-oxidation of sparteine in man: A new pharmacogenetic defect
M. Eichelbaum
,
N. Spannbrucker
,
Barbara Steincke
,
H. Dengler
European Journal of Clinical Pharmacology
2004
Corpus ID: 31974459
SummarySparteine, an antiarrhythmic and oxytocic drug, is metabolised by N1-oxidation. The sparteine-N1-oxide rearranges with…
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Review
2003
Review
2003
Role of selective serotonin reuptake inhibitors in psychiatric disorders: a comprehensive review
M. Vaswani
,
Farzana Kadar Linda
,
S. Ramesh
Progress in Neuro-Psychopharmacology and…
2003
Corpus ID: 38044451
Highly Cited
2003
Highly Cited
2003
Palladium-catalysed oxidation of primary and secondary alcohols
J. Muzart
2003
Corpus ID: 95067282
Review
2003
Review
2003
Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry
U. Zanger
,
S. Raimundo
,
M. Eichelbaum
Naunyn-Schmiedeberg's Archives of Pharmacology
2003
Corpus ID: 13205811
Of about one dozen human P450 s that catalyze biotransformations of xenobiotics, CYP2D6 is one of the more important ones based…
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Highly Cited
2001
Highly Cited
2001
The palladium-catalyzed oxidative kinetic resolution of secondary alcohols with molecular oxygen.
E. M. Ferreira
,
B. Stoltz
Journal of the American Chemical Society
2001
Corpus ID: 43511950
The oxidation of secondary alcohols is one of the most common and well-studied reactions in chemistry. Although excellent…
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Review
2000
Review
2000
Tramadol: a review of its use in perioperative pain.
L. Scott
,
C. Perry
Drugs
2000
Corpus ID: 195692881
UNLABELLED Tramadol is a synthetic, centrally acting analgesic agent with 2 distinct, synergistic mechanisms of action, acting as…
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Highly Cited
1996
Highly Cited
1996
The hypoalgesic effect of tramadol in relation to CYP2D6 *
Lars Poulsen
,
L. Arendt-Nielsen
,
K. Brøsen
,
S. H. Sindrup
Clinical pharmacology and therapeutics
1996
Corpus ID: 25472309
Highly Cited
1996
Highly Cited
1996
Codeine and morphine in extensive and poor metabolizers of sparteine: pharmacokinetics, analgesic effect and side effects
L. Poulsen
,
K. Brøsen
,
L. Arendt-Nielsen
,
L. Gram
,
K. Elbæk
,
S. Sindrup
European Journal of Clinical Pharmacology
1996
Corpus ID: 23391761
Objective:Codeine O-demethylation to morphine is catalysed by the genetic polymorphic sparteine oxygenase (CYP2D6). The objective…
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Highly Cited
1987
Highly Cited
1987
High-performance liquid chromatographic assays for bufuralol 1'-hydroxylase, debrisoquine 4-hydroxylase, and dextromethorphan O-demethylase in microsomes and purified cytochrome P-450 isozymes of…
T. Kronbach
,
D. Mathys
,
J. Gut
,
T. Catin
,
U. Meyer
Analytical biochemistry
1987
Corpus ID: 24249501
Highly Cited
1985
Highly Cited
1985
Purification and characterization of the human liver cytochromes P-450 involved in debrisoquine 4-hydroxylation and phenacetin O-deethylation, two prototypes for genetic polymorphism in oxidative…
L. Distlerath
,
P. Reilly
,
M. Martín
,
G. Davis
,
G. Wilkinson
,
F. Guengerich
The Journal of biological chemistry
1985
Corpus ID: 19381293
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