Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

Sparteine

Known as: Sparteine [Chemical/Ingredient], 7,14-Methano-2H,6H-dipyrido(1,2-a:1',2'-e)(1,5)diazocine, dodecahydro-, (7S-(7alpha,7aalpha,14alpha,14abeta))-, Sparteine, (7S-(7alpha,7aalpha,14alpha,14abeta))-Isomer 
A quinolizidine alkaloid isolated from several FABACEAE including LUPINUS; SPARTIUM; and CYTISUS. It has been used as an oxytocic and an anti… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
SummarySparteine, an antiarrhythmic and oxytocic drug, is metabolised by N1-oxidation. The sparteine-N1-oxide rearranges with… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Individuals with the cytochrome P450 (CYP) 2D6 intermediate metabolizer (IM) phenotype have low residual enzyme activity and… Expand
Is this relevant?
Highly Cited
2003
Highly Cited
2003
 
Is this relevant?
Highly Cited
2001
Highly Cited
2001
The oxidation of secondary alcohols is one of the most common and well-studied reactions in chemistry. Although excellent… Expand
Is this relevant?
Highly Cited
2000
Highly Cited
2000
  • S. Yu, D. Choi
  • Proceedings of the National Academy of Sciences…
  • 2000
  • Corpus ID: 28444570
Programmed cell death culminating in apoptosis is responsible for normal tissue homeostasis and has increasingly been implicated… Expand
  • figure 1
Is this relevant?
Highly Cited
1992
Highly Cited
1992
The relationship between the selective serotonin reuptake inhibitor paroxetine and the sparteine oxidation polymorphism was… Expand
Is this relevant?
Highly Cited
1991
Highly Cited
1991
The debrisoquine/sparteine polymorphism is associated with a clinically important genetic deficiency of oxidative drug metabolism… Expand
Is this relevant?
Review
1990
Review
1990
It has been established that the metabolism of more than twenty drugs, including antiarrhythmics, beta-adrenoceptor antagonists… Expand
Is this relevant?
Highly Cited
1990
Highly Cited
1990
The analgesic efficacy and kinetics of a single oral dose of 75 mg codeine was investigated in 12 extensive metabolizers and 12… Expand
Is this relevant?
Highly Cited
1990
Highly Cited
1990
In previous papers we demonstrated that cyclosporin A (CsA) was specifically oxidized in rabbit and human liver by cytochrome P… Expand
Is this relevant?