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Sparteine

Known as: Sparteine [Chemical/Ingredient], 7,14-Methano-2H,6H-dipyrido(1,2-a:1',2'-e)(1,5)diazocine, dodecahydro-, (7S-(7alpha,7aalpha,14alpha,14abeta))-, Sparteine, (7S-(7alpha,7aalpha,14alpha,14abeta))-Isomer 
A quinolizidine alkaloid isolated from several FABACEAE including LUPINUS; SPARTIUM; and CYTISUS. It has been used as an oxytocic and an anti… Expand
National Institutes of Health

Related topics

Related topics

27 relations

Narrower (15)

10,17-dioxosparteine13-hydroxylupanine17-oxosparteine2-dehydrosparteine
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Broader (3)

AlkaloidsAnti-Arrhythmia AgentsOxytocics
In BloodProcess of secretionagonistsanalogs & derivatives
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
Defective N-oxidation of sparteine in man: A new pharmacogenetic defect
SummarySparteine, an antiarrhythmic and oxytocic drug, is metabolised by N1-oxidation. The sparteine-N1-oxide rearranges with… Expand
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Highly Cited
2004
Highly Cited
2004
A novel intronic mutation, 2988G>A, with high predictivity for impaired dunction of cytochrome P450 2D6 in white subjects
Individuals with the cytochrome P450 (CYP) 2D6 intermediate metabolizer (IM) phenotype have low residual enzyme activity and… Expand
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Highly Cited
2003
Highly Cited
2003
Palladium-catalysed oxidation of primary and secondary alcohols
 
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Highly Cited
2001
Highly Cited
2001
The palladium-catalyzed oxidative kinetic resolution of secondary alcohols with molecular oxygen.
The oxidation of secondary alcohols is one of the most common and well-studied reactions in chemistry. Although excellent… Expand
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Highly Cited
2000
Highly Cited
2000
Ions, cell volume, and apoptosis.
  • S. Yu, D. Choi
  • Proceedings of the National Academy of Sciences…
  • 2000
    • Corpus ID: 28444570
Programmed cell death culminating in apoptosis is responsible for normal tissue homeostasis and has increasingly been implicated… Expand
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Highly Cited
1992
Highly Cited
1992
The relationship between paroxetine and the sparteine oxidation polymorphism
The relationship between the selective serotonin reuptake inhibitor paroxetine and the sparteine oxidation polymorphism was… Expand
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Highly Cited
1991
Highly Cited
1991
Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism.
The debrisoquine/sparteine polymorphism is associated with a clinically important genetic deficiency of oxidative drug metabolism… Expand
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Review
1990
Review
1990
The genetic polymorphism of debrisoquine/sparteine metabolism--clinical aspects.
It has been established that the metabolism of more than twenty drugs, including antiarrhythmics, beta-adrenoceptor antagonists… Expand
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Highly Cited
1990
Highly Cited
1990
Codeine increases pain thresholds to copper vapor laser stimuli in extensive but not poor metabolizers of sparteine
The analgesic efficacy and kinetics of a single oral dose of 75 mg codeine was investigated in 12 extensive metabolizers and 12… Expand
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Highly Cited
1990
Highly Cited
1990
Cyclosporin A drug interactions. Screening for inducers and inhibitors of cytochrome P-450 (cyclosporin A oxidase) in primary cultures of human hepatocytes and in liver microsomes.
In previous papers we demonstrated that cyclosporin A (CsA) was specifically oxidized in rabbit and human liver by cytochrome P… Expand
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