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Sparteine

Known as: Sparteine [Chemical/Ingredient], 7,14-Methano-2H,6H-dipyrido(1,2-a:1',2'-e)(1,5)diazocine, dodecahydro-, (7S-(7alpha,7aalpha,14alpha,14abeta))-, Sparteine, (7S-(7alpha,7aalpha,14alpha,14abeta))-Isomer 
A quinolizidine alkaloid isolated from several FABACEAE including LUPINUS; SPARTIUM; and CYTISUS. It has been used as an oxytocic and an anti… 
National Institutes of Health

Related topics

Related topics

27 relations

Narrower (15)

10,17-dioxosparteine13-hydroxylupanine17-oxosparteine2-dehydrosparteine
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Broader (3)

AlkaloidsAnti-Arrhythmia AgentsOxytocics
In BloodProcess of secretionagonistsanalogs & derivatives
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
Defective N-oxidation of sparteine in man: A new pharmacogenetic defect
SummarySparteine, an antiarrhythmic and oxytocic drug, is metabolised by N1-oxidation. The sparteine-N1-oxide rearranges with… 
Review
2003
Review
2003
Role of selective serotonin reuptake inhibitors in psychiatric disorders: a comprehensive review
Highly Cited
2003
Highly Cited
2003
Palladium-catalysed oxidation of primary and secondary alcohols
Review
2003
Review
2003
Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry
Of about one dozen human P450 s that catalyze biotransformations of xenobiotics, CYP2D6 is one of the more important ones based… 
Highly Cited
2001
Highly Cited
2001
The palladium-catalyzed oxidative kinetic resolution of secondary alcohols with molecular oxygen.
The oxidation of secondary alcohols is one of the most common and well-studied reactions in chemistry. Although excellent… 
Review
2000
Review
2000
Tramadol: a review of its use in perioperative pain.
UNLABELLED Tramadol is a synthetic, centrally acting analgesic agent with 2 distinct, synergistic mechanisms of action, acting as… 
Highly Cited
1996
Highly Cited
1996
The hypoalgesic effect of tramadol in relation to CYP2D6 *
Highly Cited
1996
Highly Cited
1996
Codeine and morphine in extensive and poor metabolizers of sparteine: pharmacokinetics, analgesic effect and side effects
Objective:Codeine O-demethylation to morphine is catalysed by the genetic polymorphic sparteine oxygenase (CYP2D6). The objective… 
Highly Cited
1987
Highly Cited
1987
High-performance liquid chromatographic assays for bufuralol 1'-hydroxylase, debrisoquine 4-hydroxylase, and dextromethorphan O-demethylase in microsomes and purified cytochrome P-450 isozymes of…
Highly Cited
1985
Highly Cited
1985
Purification and characterization of the human liver cytochromes P-450 involved in debrisoquine 4-hydroxylation and phenacetin O-deethylation, two prototypes for genetic polymorphism in oxidative…
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