Sparteine

Known as: Sparteine [Chemical/Ingredient], 7,14-Methano-2H,6H-dipyrido(1,2-a:1',2'-e)(1,5)diazocine, dodecahydro-, (7S-(7alpha,7aalpha,14alpha,14abeta))-, Sparteine, (7S-(7alpha,7aalpha,14alpha,14abeta))-Isomer 
A quinolizidine alkaloid isolated from several FABACEAE including LUPINUS; SPARTIUM; and CYTISUS. It has been used as an oxytocic and an anti… (More)
National Institutes of Health

Papers overview

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Highly Cited
1996
Highly Cited
1996
Objective: Codeine O-demethylation to morphine is catalysed by the genetic polymorphic sparteine oxygenase (CYP2D6). The… (More)
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Highly Cited
1994
Highly Cited
1994
The impact of gender, use of oral contraceptive steroids (OCS), coffee consumption and of smoking on the metabolism of sparteine… (More)
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Highly Cited
1991
Highly Cited
1991
Four different mutations of the cytochrome P450 CYP2D6 gene associated with the poor metabolizer phenotype (PM) of the… (More)
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Highly Cited
1991
Highly Cited
1991
The debrisoquine/sparteine polymorphism is associated with a clinically important genetic deficiency of oxidative drug metabolism… (More)
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Review
1990
Review
1990
It has been established that the metabolism of more than twenty drugs, including antiarrhythmics, beta-adrenoceptor antagonists… (More)
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Highly Cited
1990
Highly Cited
1990
The analgesic efficacy and kinetics of a single oral dose of 75 mg codeine was investigated in 12 extensive metabolizers and 12… (More)
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Review
1990
Review
1990
The genetic polymorphism of debrisoquine/sparteine metabolism is one of the best studied examples of a genetic variability in… (More)
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1985
1985
Sparteine oxidation was polymorphic among 301 healthy Danish volunteers. Hence 22 subjects or 7.3% were phenotyped as poor… (More)
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1982
1982
Thirty-eight healthy subjects were given single oral doses of debrisoquine and sparteine in a crossover study. The close… (More)
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Highly Cited
1979
Highly Cited
1979
Sparteine, an antiarrhythmic and oxytocic drug, is metabolised by N1-oxidation. The sparteine-N1-oxide rearranges with loss of… (More)
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