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Sparteine

Known as: Sparteine [Chemical/Ingredient], 7,14-Methano-2H,6H-dipyrido(1,2-a:1',2'-e)(1,5)diazocine, dodecahydro-, (7S-(7alpha,7aalpha,14alpha,14abeta))-, Sparteine, (7S-(7alpha,7aalpha,14alpha,14abeta))-Isomer 
A quinolizidine alkaloid isolated from several FABACEAE including LUPINUS; SPARTIUM; and CYTISUS. It has been used as an oxytocic and an anti… 
National Institutes of Health

Related topics

Related topics

27 relations

Narrower (15)

10,17-dioxosparteine13-hydroxylupanine17-oxosparteine2-dehydrosparteine

Broader (3)

AlkaloidsAnti-Arrhythmia AgentsOxytocics
In BloodProcess of secretionagonistsanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Sparteine oxidation polymorphism in Denmark.
Sparteine oxidation was polymorphic among 301 healthy Danish volunteers. Hence 22 subjects or 7.3% were phenotyped as poor… 
Review
2008
Review
2008
Basic instinct: design, synthesis and evaluation of (+)-sparteine surrogates for asymmetric synthesis.
(-)-Sparteine, a naturally occurring lupin alkaloid, is widely used as a chiral ligand for asymmetric synthesis. To address the… 
2002
2002
Effect of growth hormone on hepatic cytochrome P450 activity in healthy elderly men
Our objective was to study the effect of recombinant human growth hormone (rhGH) on hepatic cytochrome P450 (CYP) activity in 30… 
Review
1997
Review
1997
Impact of P450 genetic polymorphism on the first-pass extraction of cardiovascular and neuroactive drugs.
Review
1992
Review
1992
Genetically determined differences in drug metabolism as a risk factor in drug toxicity.
Highly Cited
1986
Highly Cited
1986
Sparteine oxidation is practically abolished in quinidine-treated patients.
In eight patients a sparteine-test was carried out immediately before and after 1 week of treatment with quinidine 600-800 mg day… 
Highly Cited
1984
Highly Cited
1984
Mephenytoin and sparteine pharmacogenetics in Canadian Caucasians
The frequency of genetically deficient hydroxylation of mephenytoin (M‐defect) was studied in 83 healthy Caucasians living in… 
Highly Cited
1983
Highly Cited
1983
The genetic control of sparteine and debrisoquine metabolism in man with new methods of analysing bimodal distributions.
Debrisoquine and sparteine tests were carried out in 215 random white British subjects. There is a high degree of correlation… 
1983
1983
Comparative pharmacogenetics of sparteine and debrisoquine
Capacities to oxidize sparteine and debrisoquine in healthy Canadian Caucasians were compared. The Spearman rank correlation… 
Highly Cited
1982
Highly Cited
1982
Sparteine metabolism in Canadian Caucasians
The capacity for sparteine (SP) metabolism was determined in 48 Caucasian subjects by measuring amounts of drug and… 
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