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2-dehydrosparteine

National Institutes of Health

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Broader (1)

Sparteine
analogs & derivatives

Papers overview

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1992
1992
Gas chromatography/mass spectrometry assays for the determination of debrisoquine and sparteine metabolites in microsomal fractions of rat liver.
1989
1989
Evidence in humans for variant allozymes of the nondeficient sparteine/debrisoquine monooxygenase (P45OIID 1) in vitro.
Sparteine oxidation is part of a genetic polymorphism that affects the metabolism of many drugs and is under monogenic control… 
1987
1987
Evidence for altered catalytic properties of the cytochrome P‐450 involved in sparteine oxidation in poor metabolizers
Sparteine metabolism was studied in human liver microsomes from nine extensive ([EM] urinary metabolic ratio [MR] < 20) and four… 
1986
1986
A sensitive capillary GC assay for the determination of sparteine oxidation products in microsomal fractions of human liver.
Highly Cited
1986
Highly Cited
1986
The genetic polymorphism of sparteine metabolism.
The formation of the two major metabolites of the antiarrhythmic and oxytocic drug sparteine (2- and 5-dehydrosparteine) exhibits… 
1986
1986
Sparteine oxidation polymorphism in Greenlanders living in Denmark.
Sparteine oxidation appeared to be polymorphic in 185 healthy Greenlanders living in Denmark. Six subjects (3.2%) were phenotyped… 
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