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Spaglumic Acid

Known as: NAAG 
National Institutes of Health

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Related topics

1 relation
ISOSPAGLUMIC ACID

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer
Membrane‐bound glutamate carboxypeptidase II (GCPII) is a zinc metalloenzyme that catalyzes the hydrolysis of the… 
Review
2005
Review
2005
NAAG peptidase inhibitors and their potential for diagnosis and therapy
Modulation of N-acetyl-L-aspartyl-L-glutamate peptidase activity with small-molecule inhibitors holds promise for a wide variety… 
Highly Cited
2004
Highly Cited
2004
Synthesis of urea-based inhibitors as active site probes of glutamate carboxypeptidase II: efficacy as analgesic agents.
The neuropeptidase glutamate carboxypeptidase II (GCPII) hydrolyzes N-acetyl-L-aspartyl-L-glutamate (NAAG) to liberate N… 
Highly Cited
2004
Highly Cited
2004
Identification of the N‐glycosylation sites on glutamate carboxypeptidase II necessary for proteolytic activity
Glutamate carboxypeptidase II (GCPII) is a membrane peptidase expressed in the prostate, central and peripheral nervous system… 
Highly Cited
2002
Highly Cited
2002
Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbens.
The regulation of extracellular glutamate in the nucleus accumbens by group II metabotropic glutamate receptors (mGluR2/3) was… 
Review
2001
Review
2001
Circuit analysis of NMDAR hypofunction in the hippocampus, in vitro, and psychosis of schizophrenia †
NMDA antagonists provide the best pharmacological model of psychosis‐related schizophrenia. Data from circuit analysis of the… 
Highly Cited
1999
Highly Cited
1999
Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury
We describe here a new strategy for the treatment of stroke, through the inhibition of NAALADase (N-acetylated-α-linked-acidic… 
Review
1999
Review
1999
Cognitive dysfunction in schizophrenia: unifying basic research and clinical aspects
Abstract Seeking to unite psychological and biological approaches, this paper links cognitive and cellular hypotheses and data… 
Highly Cited
1999
Highly Cited
1999
Isolation and Expression of Novel Human Glutamate Carboxypeptidases with N-Acetylated α-Linked Acidic Dipeptidase and Dipeptidyl Peptidase IV Activity*
Hydrolysis of the neuropeptideN-acetyl-l-aspartyl-l-glutamate (NAAG) by N-acetylated α-linked acidic dipeptidase (NAALADase) to… 
Highly Cited
1988
Highly Cited
1988
Hydrolysis of the Brain Dipeptide N‐Acetyl‐l‐Aspartyl‐l‐Glutamate: Subcellular and Regional Distribution, Ontogeny, and the Effect of Lesions on N‐Acetylated‐α‐Linked Acidic Dipeptidase Activity
Abstract: N‐Acetylated‐α‐linked acidic dipeptidase (NAA‐LADase) is a Cl− dependent, membrane bound, metallopeptidase that cleaves… 
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