Spaglumic Acid

Known as: NAAG 
 
National Institutes of Health

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ISOSPAGLUMIC ACID

Papers overview

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2013
2013
In vivo measurements of glutamate, GABA, and NAAG in schizophrenia.
The major excitatory and inhibitory neurotransmitters, glutamate (Glu) and gamma-aminobutyric acid (GABA), respectively, are… (More)
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Highly Cited
2006
Highly Cited
2006
Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer.
Membrane-bound glutamate carboxypeptidase II (GCPII) is a zinc metalloenzyme that catalyzes the hydrolysis of the… (More)
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Review
2005
Review
2005
NAAG peptidase inhibitors and their potential for diagnosis and therapy
Modulation of N-acetyl-L-aspartyl-L-glutamate peptidase activity with small-molecule inhibitors holds promise for a wide variety… (More)
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Highly Cited
2005
Highly Cited
2005
MR spectroscopic evidence for glial increase but not for neuro-axonal damage in MS normal-appearing white matter.
Quantitative single-voxel, short echo-time (TE) MR spectroscopy (MRS) was used to determine metabolite concentrations in the… (More)
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2004
2004
Synthesis of urea-based inhibitors as active site probes of glutamate carboxypeptidase II: efficacy as analgesic agents.
The neuropeptidase glutamate carboxypeptidase II (GCPII) hydrolyzes N-acetyl-L-aspartyl-L-glutamate (NAAG) to liberate N… (More)
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Highly Cited
2002
Highly Cited
2002
Group II metabotropic glutamate receptors modulate extracellular glutamate in the nucleus accumbens.
The regulation of extracellular glutamate in the nucleus accumbens by group II metabotropic glutamate receptors (mGluR2/3) was… (More)
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2002
2002
GCPII (NAALADase) inhibition prevents long-term diabetic neuropathy in type 1 diabetic BB/Wor rats
AIMS/HYPOTHESIS Hyperglutamatergic activity induced by ischemia is believed to underlie neuronal damage in a variety of… (More)
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Review
2001
Review
2001
Circuit analysis of NMDAR hypofunction in the hippocampus, in vitro, and psychosis of schizophrenia.
NMDA antagonists provide the best pharmacological model of psychosis-related schizophrenia. Data from circuit analysis of the… (More)
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Highly Cited
1999
Highly Cited
1999
Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury
We describe here a new strategy for the treatment of stroke, through the inhibition of NAALADase (N-acetylated-α-linked-acidic… (More)
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Review
1999
Review
1999
Cognitive dysfunction in schizophrenia: unifying basic research and clinical aspects
Seeking to unite psychological and biological approaches, this paper links cognitive and cellular hypotheses and data about… (More)
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