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Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
It is reported that natural oligomers of human Aβ are formed soon after generation of the peptide within specific intracellular vesicles and are subsequently secreted from the cell, indicating that synaptotoxic Aβ oligomers can be targeted therapeutically.
Behavioural stress facilitates the induction of long-term depression in the hippocampus
It is reported that the induction of stable homosynaptic LTD in the CA1 area of the hippocampus of awake adult rats is facilitated, rather than inhibited, by exposure to mild naturalistic stress.
Dopamine-dependent facilitation of LTP induction in hippocampal CA1 by exposure to spatial novelty
It is found that brief exposure to a novel environment lowered the threshold for the induction of LTP, and an important role for dopamine-regulated synaptic plasticity in the storage of unpredicted information in the CA1 area is supported.
Metabotropic glutamate receptors: electrophysiological properties and role in plasticity
- R. Anwyl
- BiologyBrain Research Reviews
- 31 January 1999
Metabotropic Glutamate Receptors: Electrophysiological Properties and Role in Plasticity
- R. Anwyl
- BiologyReviews in the neurosciences
The present review shows that activation of the receptor by agonists, especially ί-ACPD, has a very diverse range of electrophysiological effects that appear to be essential for the induction of two types of long-term potentiation occurring in CA1 and CA3 of the hippocampus, and also for induction ofLong-term depression in the cerebellum.
Block of Long-Term Potentiation by Naturally Secreted and Synthetic Amyloid β-Peptide in Hippocampal Slices Is Mediated via Activation of the Kinases c-Jun N-Terminal Kinase, Cyclin-Dependent Kinase…
- Qinwen Wang, D. Walsh, M. Rowan, D. Selkoe, R. Anwyl
- Biology, ChemistryThe Journal of Neuroscience
- 31 March 2004
Evidence is provided that the A β-mediated inhibition of LTP induction involves stimulation of the kinases JNK, Cdk5, and p38 MAPK after the activation of both the Aβ receptor(s) and mGluR5.
Glucocorticoid receptor and protein/RNA synthesis-dependent mechanisms underlie the control of synaptic plasticity by stress.
- L. Xu, C. Holscher, R. Anwyl, M. Rowan
- Biology, PsychologyProceedings of the National Academy of Sciences…
- 17 March 1998
It is discovered that glucocorticoid receptor activation mediates the effects of stress on LTD and long-term potentiation in a protein synthesis-dependent manner because they were prevented by the glucocortex receptor antagonist RU 38486 and the protein synthesis inhibitor emetine.
Stimulation on the Positive Phase of Hippocampal Theta Rhythm Induces Long-Term Potentiation That Can Be Depotentiated by Stimulation on the Negative Phase in Area CA1 In Vivo
It is shown that a single burst of five pulses given on the positive phase of tail pinch-triggered theta rhythm reliably induced LTP in the stratum radiatum of the hippocampus of urethane-anesthetized rats.
Overcoming the Effects of Stress on Synaptic Plasticity in the Intact Hippocampus: Rapid Actions of Serotonergic and Antidepressant Agents
Findings show that antidepressants have rapid and powerful interactions with the mechanisms controlling the persistence of the block of LTP by inescapable stress.
β-Amyloid-Mediated Inhibition of NMDA Receptor-Dependent Long-Term Potentiation Induction Involves Activation of Microglia and Stimulation of Inducible Nitric Oxide Synthase and Superoxide
Evidence is presented that the Aβ-mediated inhibition of LTP induction involves an inflammatory-type reaction in which activation of microglia results in the production of nitric oxide and superoxide and thence possibly peroxynitrite, a highly reactive oxidant.