A pharmacologic strategy for the treatment of nicotine addiction
- S. Dewey, J. Brodie, M. Gerasimov, B. Horan, E. Gardner, C. Ashby
- BiologySynapse
- 1 January 1999
The utility of gamma vinyl‐GABA (GVG, Vigabatrin) for inhibiting nicotine's biochemical effects on NAc DA as well as its effects on behaviors associated with these biochemical changes are examined to suggest that GVG may be useful for the treatment of nicotine addiction.
Acute administration of the selective D3 receptor antagonist SB‐277011A blocks the acquisition and expression of the conditioned place preference response to heroin in male rats
- C. Ashby, Mousumi Paul, E. Gardner, Christian A. Heidbreder, J. Hagan
- Biology, MedicineSynapse
- 1 June 2003
This research presents a novel and scalable approach called “SmartPharmacy’s SmartPharm,” which combines a probabilistic approach to drug discovery with a simple and scalable “situational awareness” approach that works well in both the clinic and the laboratory.
Electrophysiological evidence for a functional interaction between 5‐HT1A and 5‐HT2A receptors in the rat medial prefrontal cortex: An lontophoretic study
- C. Ashby, E. Edwards, Rex Y. Wang
- Biology, ChemistrySynapse
- 1 July 1994
Results confirm and extend the hypothesis that there is an interaction between 5‐HT1A and5‐HT2A receptors in the mPFc at the neuronal level.
Expression and acquisition of the conditioned place preference response to cocaine in rats is blocked by selective inhibitors of the enzyme N‐acetylated‐α‐linked‐acidic dipeptidase (NAALADASE)
- B. Slusher, A. Thomas, Mousumi Paul, Christina A. Schad, C. Ashby
- Biology, PsychologySynapse
- 1 July 2001
The results indicate that NAALADase inhibitors block the incentive motivational value of cocaine, suggesting that such agents may be of use in treating cue‐induced craving in cocaine addicts.
The highly selective 5‐hydroxytryptamine (5‐HT)2A receptor antagonist, EMD 281014, significantly increases swimming and decreases immobility in male congenital learned helpless rats in the forced…
- Jignesh G. Patel, Gerd D. Bartoszyk, E. Edwards, C. Ashby
- BiologySynapse
- 1 April 2004
Effect of EMD 281014 produces effects in the forced swim test resembling those of antidepressants.
Pharmacological actions of the atypical antipsychotic drug clozapine: A review
- C. Ashby, Rex Y. Wang
- Psychology, MedicineSynapse
- 1 December 1996
Clozapine is therapeutically effective in treating about 30% of schizophrenic patients who are resistant to standard antipsychotic drugs and has a much lower propensity for inducing neurological side effects after acute or repeated administration compared to various typical neuroleptics.
Gamma‐vinyl GABA inhibits methamphetamine, heroin, or ethanol‐induced increases in nucleus accumbens dopamine
- M. Gerasimov, C. Ashby, E. Gardner, Mark J. Mills, J. Brodie, S. Dewey
- Biology, MedicineSynapse
- 1 October 1999
Results indicate that GVG attenuates increases in NAc DA by a mechanism common to many drugs of abuse, however, it appears unlikely that an acute dose of GVG can completely inhibit increases inNAc DA following challenges with a drug whose mechanism of action is mediated primarily through the DA reuptake site.
Effect of acute and chronic fluoxetine on extracellular dopamine levels in the caudate‐putamen and nucleus accumbens of rat
- Robert N. Clark, C. Ashby, S. Dewey, P. Ramachandran, R. Strecker
- Biology, PsychologySynapse
- 1 July 1996
The 5‐HT‐induced facilitation of NAc DA neurotransmission described in the literature may not be relevant to the therapeutic action of fluoxetine.
Effect of acute and chronic administration of the selective 5‐HT2C receptor antagonist SB‐243213 on midbrain dopamine neurons in the rat: An in vivo extracellular single cell study
- T. Blackburn, Y. Minabe, Derek N. Middlemiss, Y. Shirayama, K. Hashimoto, C. Ashby
- Biology, ChemistrySynapse
- 1 December 2002
The results indicate that antagonism of the 5‐HT2C receptor alters the activity of midbrain DA neurons in anesthetized rats and suggest that SB‐243213 has an atypical antipsychotic profile following chronic administration.
Acute and chronic administration of the selective sigma1 receptor agonist SA4503 significantly alters the activity of midbrain dopamine neurons in rats: An in vivo electrophysiological study
- Y. Minabe, K. Matsuno, C. Ashby
- Biology, Chemistry
- 1 August 1999
The results suggest that the administration of SA4503 significantly alters the activity of spontaneously active midbrain DA neurons, particularly those in the VTA following repeated administration.
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