Oxidative stress, glutamate, and neurodegenerative disorders.
Two broad mechanisms--oxidative stress and excessive activation of glutamate receptors--are converging and represent sequential as well as interacting processes that provide a final common pathway for cell vulnerability in the brain.
Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia
Glutamate and Schizophrenia: Beyond the Dopamine Hypothesis
- J. Coyle
- Psychology, MedicineCellular and molecular neurobiology
- 14 June 2006
Hypofunction of the NMDA receptor, possibly on critical GABAergic inter-neurons, may contribute to the pathophysiology of schizophrenia.
Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain.
- P. Whitehouse, D. Price, R. Struble, A. Clark, J. Coyle, M. Delon
- Biology, PsychologyScience
- 5 March 1982
Demonstration of selective degeneration of neurons of the nucleus basalis of Meynert represents the first documentation of a loss of a transmitter-specific neuronal population in a major disorder of higher cortical function and points to a critical subcortical lesion in Alzheimer's patients.
Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress
Neurobiology of Schizophrenia
Alzheimer's disease: a disorder of cortical cholinergic innervation.
Advances in neurotransmitter systems involved in the symptomatic manifestations of neurological and psychiatric disorders reflect a close interaction between experimental and clinical neuroscientists in which information derived from basic neurobiology is rapidly utilized to analyze disorders of the human brain.
Review of the Toxicology of Chlorpyrifos With an Emphasis on Human Exposure and Neurodevelopment
The results of this review demonstrate that the use of urinary 3,5,6-trichlorpyridinol (TCPy), a metabolite of chlorpyrifos as a biomarker of nonoccupational exposure is problematic and may overestimate non Occupational exposures to chlorparyifos by 10-to 20-fold because of the widespread presence of both TCPy and chlorp Pyrifos-methyl in the food supply.
D-serine added to antipsychotics for the treatment of schizophrenia
The emerging role of glutamate in the pathophysiology and treatment of schizophrenia.
Dysfunction of glutamatergic neurotransmission may play an important role in the pathophysiology of schizophrenia, especially of the negative symptoms and cognitive impairments associated with the disorder, and is a promising target for drug development.