J. Coyle

Publications558
h-index113
Citations59,629
Highly Influential Citations1,236
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Oxidative stress, glutamate, and neurodegenerative disorders.
TLDR
Two broad mechanisms--oxidative stress and excessive activation of glutamate receptors--are converging and represent sequential as well as interacting processes that provide a final common pathway for cell vulnerability in the brain.
Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia
TLDR
A circuit-based framework for understanding gene and neurotransmitter interactions in schizophrenia is developed and Nicotine enhances the output of interneurons, and might thereby contribute to its therapeutic effect in schizophrenia.
Glutamate and Schizophrenia: Beyond the Dopamine Hypothesis
  • J. Coyle
  • Medicine
    Cellular and Molecular Neurobiology
  • 14 June 2006
TLDR
Hypofunction of the NMDA receptor, possibly on critical GABAergic inter-neurons, may contribute to the pathophysiology of schizophrenia.
Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain.
TLDR
Demonstration of selective degeneration of neurons of the nucleus basalis of Meynert represents the first documentation of a loss of a transmitter-specific neuronal population in a major disorder of higher cortical function and points to a critical subcortical lesion in Alzheimer's patients.
Review of the Toxicology of Chlorpyrifos With an Emphasis on Human Exposure and Neurodevelopment
This review examines the large body of toxicological and epidemiological information on human exposures to chlorpyrifos, with an emphasis on the controversial potential for chlorpyrifos to induce…
Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress
TLDR
Glutamate-induced cytotoxicity in N18-RE-105 cells is due to inhibition of cystine uptake, resulting in lowered glutathione levels leading to oxidative stress and cell death.
Neurobiology of Schizophrenia
TLDR
It is suggested that DISC1 may offer especially valuable insights into the pathogenesis of schizophrenia and help redefine the schizophrenia phenotype and shed light on the relationship between schizophrenia and other major psychiatric disorders.
Alzheimer's disease: a disorder of cortical cholinergic innervation.
TLDR
Advances in neurotransmitter systems involved in the symptomatic manifestations of neurological and psychiatric disorders reflect a close interaction between experimental and clinical neuroscientists in which information derived from basic neurobiology is rapidly utilized to analyze disorders of the human brain.
D-serine added to antipsychotics for the treatment of schizophrenia
TLDR
A significant improvement in patients who received D-serine treatment revealed significant improvements in their positive, negative, and cognitive symptoms as well as some performance in Wisconsin Card Sorting Test (WCST).
The emerging role of glutamate in the pathophysiology and treatment of schizophrenia.
  • D. Goff, J. Coyle
  • Psychology, Medicine
    The American journal of psychiatry
  • 1 September 2001
TLDR
Dysfunction of glutamatergic neurotransmission may play an important role in the pathophysiology of schizophrenia, especially of the negative symptoms and cognitive impairments associated with the disorder, and is a promising target for drug development.
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