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Sp1 Transcription Factor

Known as: Transcription Factor, Sp1, Sp1 Transcription Factor [Chemical/Ingredient], Specificity Protein 1 Transcription Factor 
Promoter-specific RNA polymerase II transcription factor that binds to the GC box, one of the upstream promoter elements, in mammalian cells. The… 
National Institutes of Health

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Related topics

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Agrin PathwayCYS2-HIS2 Zinc FingersCalcineurin PathwayDNA-Binding Proteins

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Highly Cited
2016
Highly Cited
2016
Up‐regulation of histone methyltransferase SETDB1 by multiple mechanisms in hepatocellular carcinoma promotes cancer metastasis
Epigenetic deregulation plays an important role in liver carcinogenesis. Using transcriptome sequencing, we examined the… 
Highly Cited
2005
Highly Cited
2005
Role of Histone Deacetylation in Cell-specific Expression of Endothelial Nitric-oxide Synthase*
Histone acetylation plays an important role in chromatin remodeling and gene expression. The molecular mechanisms involved in… 
2001
2001
The human tuftelin gene: cloning and characterization.
Highly Cited
2000
Highly Cited
2000
Sp1 and C/EBP are necessary to activate the lactoferrin gene promoter during myeloid differentiation.
In this study, we sought to identify factors responsible for the positive modulation of lactoferrin (LF), a neutrophil-specific… 
Highly Cited
1999
Highly Cited
1999
Sp3 and Sp4 Can Repress Transcription by Competing with Sp1 for the Core cis-Elements on the Human ADH5/FDHMinimal Promoter*
The human alcohol dehydrogenase 5 gene (also known as the formaldehyde dehydrogenase gene, ADH5/FDH) has a GC-rich promoter with… 
Highly Cited
1999
Highly Cited
1999
Native and Oxidized Low Density Lipoprotein Induction of Tissue Factor Gene Expression in Smooth Muscle Cells Is Mediated by Both Egr-1 and Sp1*
Tissue factor, in association with factor VIIa, initiates the coagulation cascade. We studied the influences of two… 
Highly Cited
1997
Highly Cited
1997
Casein Kinase II-mediated Phosphorylation of the C Terminus of Sp1 Decreases Its DNA Binding Activity*
We have previously observed that Sp1, a ubiquitous zinc finger transcription factor, is phosphorylated during terminal… 
Highly Cited
1996
Highly Cited
1996
The Role of the Transcription Factor Sp1 in Regulating the Expression of the WAF1/CIP1 Gene in U937 Leukemic Cells (*)
The Waf1/Cip1 protein induces cell cycle arrest through inhibition of the activity of cyclin-dependent kinases and proliferating… 
Highly Cited
1995
Highly Cited
1995
p53 and Sp1 Interact and Cooperate in the Tumor Necrosis Factor-induced Transcriptional Activation of the HIV-1 Long Terminal Repeat (*)
Tumor necrosis factor α (TNF) is a potent activator of transcription directed by the human immunodeficiency virus type 1 (HIV-1… 
Highly Cited
1992
Highly Cited
1992
Regulation of transcription from the hepatitis B virus major surface antigen promoter by the Sp1 transcription factor
The DNA-binding proteins which recognize the regulatory sequence elements of the hepatitis B virus (HBV) major surface antigen… 
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