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CHEK2 is a multiorgan cancer susceptibility gene.
A single founder allele of the CHEK2 gene has been associated with predisposition to breast and prostate cancer in North America and Europe. The CHEK2 protein participates in the DNA damage responseExpand
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A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor–negative breast cancer in the general population
Germline BRCA1 mutations predispose to breast cancer. To identify genetic modifiers of this risk, we performed a genome-wide association study in 1,193 individuals with BRCA1 mutations who wereExpand
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Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer
TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed ∼480 SNPs at the TERT locus inExpand
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Impact of oophorectomy on cancer incidence and mortality in women with a BRCA1 or BRCA2 mutation.
PURPOSE The purposes of this study were to estimate the reduction in risk of ovarian, fallopian tube, or peritoneal cancer in women with a BRCA1 or BRCA2 mutation after oophorectomy, by age ofExpand
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Risk of breast cancer in women with a CHEK2 mutation with and without a family history of breast cancer.
PURPOSE To estimate the risk of breast cancer in a woman who has a CHEK2 mutation depending on her family history of breast cancer. PATIENTS AND METHODS Seven thousand four hundred ninety-fourExpand
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Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array
Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a custom IlluminaExpand
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A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer
Genome-wide association studies (GWAS) have identified 76 variants associated with prostate cancer risk predominantly in populations of European ancestry. To identify additional susceptibility lociExpand
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Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer.
IMPORTANCE Limited information about the relationship between specific mutations in BRCA1 or BRCA2 (BRCA1/2) and cancer risk exists. OBJECTIVE To identify mutation-specific cancer risks forExpand
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A high proportion of founder BRCA1 mutations in Polish breast cancer families
Three mutations in BRCA1 (5382insC, C61G and 4153delA) are common in Poland and account for the majority of mutations identified to date in Polish breast and breast–ovarian cancer families. It is notExpand
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Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci
Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data from a customExpand
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