Single Strand Break Repair

Known as: Single-Strand Break Repair 
The repair of single strand breaks in DNA. Repair of such breaks is mediated by the same enzyme systems as are used in base excision repair. [http… (More)
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Cells are exposed to various endogenous and exogenous insults that induce DNA damage, which, if unrepaired, impairs genome… (More)
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Review
2007
Review
2007
Thousands of cellular single-strand breaks (SSBs) arise in cells each day, from attack of deoxyribose and DNA bases by reactive… (More)
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Highly Cited
2007
Highly Cited
2007
Defective Tyrosyl-DNA phosphodiesterase 1 (TDP1) can cause spinocerebellar ataxia with axonal neuropathy (SCAN1), a… (More)
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Highly Cited
2007
Highly Cited
2007
Single-strand breaks are the commonest lesions arising in cells, and defects in their repair are implicated in neurodegenerative… (More)
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Highly Cited
2006
Highly Cited
2006
Poly(ADP-ribose)polymerase 1 (PARP-1) recognizes DNA strand interruptions in vivo and triggers its own modification as well as… (More)
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Highly Cited
2005
Highly Cited
2005
Spinocerebellar ataxia with axonal neuropathy-1 (SCAN1) is a neurodegenerative disease that results from mutation of tyrosyl… (More)
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Highly Cited
2002
Highly Cited
2002
XRCC1 protein is required for the repair of DNA single-strand breaks and genetic stability, and is essential for viability in… (More)
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Highly Cited
2002
Highly Cited
2002
The DNA single-strand break repair (SSBR) protein XRCC1 is required for genetic stability and for embryonic viability. XRCC1… (More)
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Highly Cited
2001
Highly Cited
2001
XRCC1 protein is required for DNA single-strand break repair and genetic stability but its biochemical role is unknown. Here, we… (More)
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Review
2001
Review
2001
The genetic stability of living cells is continuously threatened by the presence of endogenous reactive oxygen species and other… (More)
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