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Serotonin 5-HT4 Receptor Agonists

Known as: Agonist, 5-HT4, 5-HT4 Agonists, 5 HT4 Agonists 
Endogenous compounds and drugs that specifically stimulate SEROTONIN 5-HT4 RECEPTORS.
National Institutes of Health

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ATI 7505CJ 033466
In Bloodaspects of radiation effectschemical synthesisphysiological aspects
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Papers overview

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Highly Cited
2014
Highly Cited
2014
Rapid Anxiolytic Effects of a 5-HT4 Receptor Agonist Are Mediated by a Neurogenesis-Independent Mechanism
Selective serotonin reuptake inhibitors (SSRIs) display a delayed onset of action of several weeks. Past work in naive rats… Expand
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Highly Cited
2010
Highly Cited
2010
Clinical trial: the efficacy and tolerability of velusetrag, a selective 5-HT4 agonist with high intrinsic activity, in chronic idiopathic constipation - a 4-week, randomized, double-blind, placebo…
BACKGROUND Velusetrag is an orally active 5-HT(4) receptor agonist of potential benefit in treating chronic idiopathic… Expand
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Highly Cited
2009
Highly Cited
2009
5-HT4 receptor-mediated neuroprotection and neurogenesis in the enteric nervous system of adult mice.
Although the mature enteric nervous system (ENS) has been shown to retain stem cells, enteric neurogenesis has not previously… Expand
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Highly Cited
2008
Highly Cited
2008
Rikkunshito, an herbal medicine, suppresses cisplatin-induced anorexia in rats via 5-HT2 receptor antagonism.
BACKGROUND & AIMS Chemotherapy with an anticancer agent generally causes gastrointestinal tract disorders such as vomiting and… Expand
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2007
2007
VRX-03011, a novel 5-HT4 agonist, enhances memory and hippocampal acetylcholine efflux
Recent evidence suggests that 5-hydroxytryptamine (5-HT)(4) receptor activity enhances cognition and provides neuroprotection… Expand
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Highly Cited
2005
Highly Cited
2005
Mosapride citrate, a novel 5-HT4 agonist and partial 5-HT3 antagonist, ameliorates constipation in parkinsonian patients.
Mosapride citrate is a novel selective 5-HT4 receptor agonist. It facilitates acetylcholine release from the enteric cholinergic… Expand
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2002
2002
5-HT4 receptors exert a frequency-related facilitatory control on dorsal raphé nucleus 5-HT neuronal activity.
We investigated, using single-unit recordings in chloral hydrate-anaesthetized rats, the role of serotonin 4 (5-HT4) receptors in… Expand
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Review
2001
Review
2001
The role of serotonin in the pathophysiology of irritable bowel syndrome.
Coordinated activities of the central, autonomic, and enteric nervous systems modulate intestinal motor, sensory, and secretory… Expand
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Highly Cited
1998
Highly Cited
1998
5-Hydroxytryptamine4 receptor agonists initiate the peristaltic reflex in human, rat, and guinea pig intestine.
BACKGROUND & AIMS The peristaltic reflex induced by mucosal stimuli is mediated by intrinsic sensory calcitonin gene-related… Expand
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1997
1997
Serotonin stimulation of 5-HT4 receptors indirectly enhances in vivo dopamine release in the rat striatum.
Serotonin (5-HT) applied at 1, 3, and 10 microM into the striatum of halothane-anesthetized rats by in vivo microdialysis… Expand
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