Enhanced tonic GABAA inhibition in typical absence epilepsy
It is shown that extrasynaptic GABAA receptor–dependent 'tonic' inhibition is increased in thalamocortical neurons from diverse genetic and pharmacological models of absence seizures, identifying an apparently common cellular pathology in typical absence seizures that may have epileptogenic importance and highlight potential therapeutic targets for the treatment of absence epilepsy.
Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies
It is concluded that answering key questions on the relationship between Aβ and tau pathology should lead to a better understanding of the nature of secondary tauopathies, especially AD, and open new therapeutic targets and strategies.
Serotonin modulation of the basal ganglia circuitry: therapeutic implication for Parkinson's disease and other motor disorders.
Essential Thalamic Contribution to Slow Waves of Natural Sleep
It is demonstrated that the thalamus finely tunes the frequency of slow waves during non-REM sleep and anesthesia, and thus provides the first conclusive evidence that a dynamic interplay of the neocortical and thalamic oscillators ofSlow waves is required for the full expression of this key physiological EEG rhythm.
GABAB Receptors Regulate Extrasynaptic GABAA Receptors
It is shown that in rat brain slices, activation of postsynaptic GABAB receptors enhances the magnitude of the tonic GABAA current recorded in these cell types via a pathway involving Gi/o G proteins, adenylate cyclase, and cAMP-dependent protein kinase, independent of potassium channels or GABA transporters.
Role of Serotonin in Central Dopamine Dysfunction
- G. Di Giovanni, E. Esposito, V. di Matteo
- Biology, ChemistryCNS Neuroscience & Therapeutics
- 1 June 2010
The recent development of subtype‐selective ligands for 5‐HT receptors will not only allow a detailed understanding of this interaction but also will lead to the development of new treatment strategies, appropriate for those neuropsychiatric disorders in which an alteration of the 5‐ HT/DA balance is supposed.
Impact of Serotonin 2C Receptor Null Mutation on Physiology and Behavior Associated with Nigrostriatal Dopamine Pathway Function
It is concluded that 5-HT2CRs regulate nigrostriatal dopaminergic activity and function both at SNc dopamine neurons and at a locus downstream of the DSt, which was suggested by enhanced behavioral responses of mutant mice to the D1 receptor agonist SKF 81297.
Oligodendrocyte Pathophysiology and Treatment Strategies in Cerebral Ischemia
- Gabriella Mifsud, C. Zammit, R. Muscat, G. Di Giovanni, M. Valentino
- BiologyCNS Neuroscience & Therapeutics
- 1 July 2014
The OL is a primary target of ischemia in adult‐onset stroke and especially in periventricular leukomalacia and should be considered as a primary therapeutic target in these conditions.
Preferential modulation of mesolimbic vs. nigrostriatal dopaminergic function by serotonin2C/2B receptor agonists: a combined in vivo electrophysiological and microdialysis study
Data indicate that mCPP and MK 212 selectively inhibit mesolimbic dopaminergic function by acting on 5‐HT2C receptors, and might be useful in clinical conditions where it is necessary to reduce the meslimbic dopamine activity without affecting the nigrostriatal function.
The central role of aquaporins in the pathophysiology of ischemic stroke
- J. Vella, C. Zammit, G. Di Giovanni, R. Muscat, M. Valentino
- BiologyFrontiers in Cellular Neuroscience
- 8 April 2015
In models of vasogenic edema, brain swelling is more pronounced in AQP4-null mice than wild-type providing strong evidence of the dual role of AQP 4 in the formation and resolution of both vasogenic and cytotoxic edema.