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The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut–brain communication
- P. Bercik, A. Park, +14 authors E. Verdu
- Biology, MedicineNeurogastroenterology and motility : the official…
- 1 December 2011
The probiotic Bifidobacterium longum NCC3001 normalizes anxiety‐like behavior and hippocampal brain derived neurotrophic factor (BDNF) in mice with infectious colitis and test whether the anxiolytic effect of B. longum involves vagal integrity, and changes in neural cell function.
Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia-reperfusion damage.
- A. Webb, R. Bond, P. Mclean, R. Uppal, N. Benjamin, A. Ahluwalia
- Chemistry, MedicineProceedings of the National Academy of Sciences…
- 14 September 2004
Nitric oxide (NO.) is thought to protect against the damaging effects of myocardial ischemia-reperfusion injury, whereas xanthine oxidoreductase (XOR) normally causes damage through the generation of…
Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment.
- A. Ahluwalia, P. Foster, +5 authors A. Hobbs
- Biology, MedicineProceedings of the National Academy of Sciences…
- 3 February 2004
It is demonstrated that sGC plays a key antiinflammatory role by inhibiting P-selectin expression and leukocyte recruitment and selective down-regulation of P- selectin expression accounted for the antiadhesive effects of sGC activation.
Protease-Activated Receptor-2 Activation Causes EDHF-Like Coronary Vasodilation: Selective Preservation in Ischemia/Reperfusion Injury: Involvement of Lipoxygenase Products, VR1 Receptors, and…
This study shows, for the first time, that PAR2 activation causes endothelium-dependent coronary vasodilation that is preserved after I/R injury and is not mediated by NO or prostanoids, but involves the release of an endothelia-derived hyperpolarizing factor (EDHF), possibly a lipoxygenase-derived eicosanoid, and activation of VR1 receptors on sensory C-fibers.
Association between Kinin B1 Receptor Expression and Leukocyte Trafficking across Mouse Mesenteric Postcapillary Venules
- P. Mclean, A. Ahluwalia, M. Perretti
- Biology, MedicineThe Journal of experimental medicine
- 7 August 2000
It is shown that B1 receptors play an important role in the mediation of leukocyte–endothelial cell interactions in postcapillary venules, leading to leukocytes recruitment during an inflammatory response.
Targeting Gut T Cell Ca2+ Release-Activated Ca2+ Channels Inhibits T Cell Cytokine Production and T-Box Transcription Factor T-Bet in Inflammatory Bowel Disease
- A. Di Sabatino, L. Rovedatti, +15 authors L. Kruidenier
- Biology, MedicineThe Journal of Immunology
- 1 September 2009
Evidence is provided that the suppression of CRAC channel function may dampen the increased T cell response in the inflamed gut, thus suggesting a promising role for CRAC inhibitor drugs in the therapeutic management of patients with IBD.
Lipocortin 1 reduces myocardial ischemia‐reperfusion injury by affecting local leukocyte recruitment
- Michele D’ Amico, C. Di Filippo, +5 authors M. Perretti
- MedicineFASEB journal : official publication of the…
- 1 October 2000
It is demonstrated for the first time that LC1 reduces the leukocyte‐dependent myocardial damage associated with an ischemia‐reperfusion procedure.
Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome
- N. Jiménez-Vargas, Luke A. Pattison, +24 authors N. Bunnett
- Medicine, ChemistryProceedings of the National Academy of Sciences
- 16 July 2018
The results reveal that PAR2 signaling from endosomes underlies the persistent hyperexcitability of nociceptors that mediates chronic pain of IBS, and reveal the therapeutic potential of endosomally targeted PAR2 antagonists for IBS pain.
Characterisation of a postjunctional 5-ht7-like and a prejunctional 5-HT3 receptor mediating contraction of rat isolated jejunum.
It is suggested that rat jejunum contains a neuronal 5-HT3 receptor facilitating neurokinin release and a contractile smooth muscle 5- HT receptor with a pharmacological operational profile similar to the cloned 5-ht7 receptor.
Transplantation of fecal microbiota from patients with irritable bowel syndrome alters gut function and behavior in recipient mice
- G. De Palma, M. Lynch, +18 authors P. Bercik
- Biology, MedicineScience Translational Medicine
- 1 March 2017
It is demonstrated that transplantation of fecal microbiota from patients with irritable bowel syndrome and anxiety resulted in altered gut function and behavior in mouse recipients, including faster gastrointestinal transit, low-grade inflammation, and anxiety-like behavior.