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Serine/Threonine Kinase Inhibitor

Any substance that inhibits serine/threonine protein kinase, an enzyme that phosphorylates the hydroxyl group of serine or threonine on various… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Protein kinase C-beta II (PKC-βII) expression in patients with colorectal cancer
PurposeCurrent development of targeted agents for the treatment of colorectal cancer include the clinical evaluation of kinase… 
Highly Cited
2008
Highly Cited
2008
Enzastaurin, an oral serine/threonine kinase inhibitor, as second- or third-line therapy of non-small-cell lung cancer.
PURPOSE Enzastaurin, an oral serine/threonine kinase inhibitor, suppresses protein kinase C (PKC) and protein kinase B/AK… 
2007
2007
Ligusticum chuanxiong prevents rat pheochromocytoma cells from serum deprivation-induced apoptosis through a protein kinase A-dependent pathway.
Review
2007
Review
2007
Enzastaurin , a Protein Kinase C B ^ Selective Inhibitor , and Its PotentialApplicationasanAnticancer AgentinLungCancer
Enzastaurin, an oral serine/threonine kinase inhibitor, suppresses signaling throughprotein kinase C (PKC)-h and the… 
2002
2002
Molecular basis of the synergistic production of IL-1 receptor antagonist by human neutrophils stimulated with IL-4 and IL-10.
In this study, we report that the release of IL-1 receptor antagonist (IL-1ra) from IL-4-stimulated neutrophils is markedly… 
Highly Cited
1999
Highly Cited
1999
Early events in the signal pathway for the oxidative burst in soybean cells exposed to avirulent pseudomonas syringae pv glycinea
Soybean (Glycine max) cv Williams 82 suspension cultures exhibit an oxidative burst approximately 3 h after challenge with… 
1999
1999
Casein Kinase II Activity Is Required for Transferrin Receptor Endocytosis*
The effect of protein kinase inhibitors on transferrin receptor (TR) internalization was examined in HeLa, A431, 3T3-L1 cells… 
1999
1999
Ceramide inhibits L-type calcium channel currents in rat pinealocytes.
In rat pinealocytes, ceramide can inhibit the KCland BayK 8644mediated potentiation of cAMP and cGMP accumulation, suggesting… 
1999
1999
Ceramide Inhibits L-Type Calcium Channel Currents in Rat Pinealocytes1.
In rat pinealocytes, ceramide can inhibit the KCl- and BayK 8644-mediated potentiation of cAMP and cGMP accumulation, suggesting… 
1996
1996
The phosphatase inhibitor calyculin antagonizes the rapid initiation of apoptosis by photodynamic therapy.
DNA fragmentation and internucleosomal cleavage were rapidly initiated after lysosomal photodamage to murine leukemia cells, with… 
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