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The neutrophil as a cellular source of chemokines
Neutrophils are known to play an important role in inflammatory responses by virtue of their ability to perform a series of effector functions that collectively represent a major mechanism of innateExpand
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Induction and regulatory function of miR-9 in human monocytes and neutrophils exposed to proinflammatory signals
Inflammation involves a coordinated, sequential, and self limiting sequence of events controlled by positive and negative regulatory mechanisms. Recent studies have shown that microRNAs (miRNAs), anExpand
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Neutrophil-derived proteins: selling cytokines by the pound.
Publisher Summary This chapter summarizes the recent knowledge on the production of cytokines by neutrophils in vitro and in vivo—particularly molecular regulation and other biological andExpand
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The production of cytokines by polymorphonuclear neutrophils.
Cytokines orchestrate the complex network of cellular interactions that regulate effector cell functions of natural and immune resistance. Although T cells, natural killer (NK) cells andExpand
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Activation of microglial cells by beta-amyloid protein and interferon-gamma.
Alzheimer's disease is the most common cause of progressive intellectual failure. The lesions that develop, called senile plaques, are extracellular deposits principally composed of insolubleExpand
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Evidence for a cross-talk between human neutrophils and Th17 cells.
Interleukin-17A (IL-17A) and IL-17F are 2 of several cytokines produced by T helper 17 cells (Th17), which are able to indirectly induce the recruitment of neutrophils. Recently, human Th17 cellsExpand
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Involvement of Suppressor of Cytokine Signaling-3 as a Mediator of the Inhibitory Effects of IL-10 on Lipopolysaccharide-Induced Macrophage Activation1
Previous studies have shown that IL-10 can induce the expression of the suppressor of cytokine signaling 3 (SOCS-3) mRNA in human monocytes and neutrophils, suggesting that the capacity of IL-10 toExpand
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Activation of microglial cells by β-amyloid protein and interferon-γ
ALZHEIMER'S disease is the most common cause of progressive intellectual failure1. The lesions that develop, called senile plaques, are extracellular deposits principally composed of insolubleExpand
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The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps
The long pentraxin (PTX) 3 is produced by macrophages and myeloid dendritic cells in response to Toll-like receptor agonists and represents a nonredundant component of humoral innate immunity againstExpand
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Toll-like receptor-3-activated human mesenchymal stromal cells significantly prolong the survival and function of neutrophils.
Bone marrow-derived mesenchymal stromal cells (BM-MSCs) are stromal precursors endowed with extensive immunomodulative properties. In this study, we aimed to assess whether Toll-like receptor-3Expand
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