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Deciphering the neuroprotective mechanisms of Bu-yang Huan-wu decoction by an integrative neurofunctional and genomic approach in ischemic stroke mice.
It is suggested that BHD is able to protect mice against stroke and extend lifespan primarily through a significant down- regulation of genes involved in inflammation, apoptosis, angiogenesis and blood coagulation, as well as an up-regulation of genes mediating neurogenesis and nervous system development. Expand
In vitro protective effects of salvianolic acid B on primary hepatocytes and hepatic stellate cells.
The results suggest that Sal B ameliorated oxidative damage and eliminated ROS accumulation in hepatocytes, and attenuated HSC activation, potentially conferring hepatoprotective and anti-fibrogenic effects. Expand
Neuroprotective principles from Gastrodia elata.
Serum deprivation-induced neuronal-like PC12 cell apoptosis was used as an ischemic/hypoxic model to screen neuroprotective compounds from the rhizomes of Gastrodia elata, a traditional ChineseExpand
Activation of AMP-activated protein kinase α1 mediates mislocalization of TDP-43 in amyotrophic lateral sclerosis.
It is demonstrated that activation of AMPK-α1 plays a critical role in TDP-43 mislocalization and the development of ALS; thus, AM PK- α1 may be a potential drug target for this devastating disease. Expand
Two New Clerodane-Type Diterpenoids, Clerodinins A and B, from Clerodendron brachyanthum SCHAUER
Two neoclerodane diterpenoids, clerodinins A and B, together with three known compounds, clerodin, stigmasta-5, 22, 25-trien-3β-ol and 3-epi-glutinol, have been isolated from the hexane extract ofExpand
Downregulation of hepatic stellate cell activation by retinol and palmitate mediated by adipose differentiation‐related protein (ADRP)
ADRP upregulation mediated by retinol and palmitate promotes downregulation of HSC activation and is functionally linked to the expression of fibrogenic genes. Expand
Inhibition of endothelial adhesion molecule expression by Monascus purpureus-fermented rice metabolites, monacolin K, ankaflavin, and monascin.
Monascus-fermented rice metabolites reduced TNF-α-stimulated endothelial adhesiveness as well as downregulating intracellular ROS formation, NF-κB activation, and VCAM-1/E-selectin expression in HAECs, supporting the notion that the various metabolites from Monascus-FERmented rice might have potential implications in clinical atherosclerosis disease. Expand
Flavonoid Glycosides from Terminalia catappa L.
Under the inhibition of Cu+2-induced LDL oxidation-guided fractionation, two new flavone glycosides with galloyl substitution were isolated from the dried fallen leaves of Terminalia catappa L. TheirExpand
Glycyrrhetinic acid suppressed NF-κB activation in TNF-α-induced hepatocytes.
The results suggest that glycyrrhetinic acid may provide hepatoprotection against chronic liver inflammation through attenuating NF-κB activation to alleviate the inflammation. Expand
Antioxidative caffeoylquinic acids and flavonoids from Hemerocallis fulva flowers.
The caffeoylquinic acid derivatives are the major components with potent free radical scavenging activity in HepG2 cells and are for the first time isolated from H. fulva flowers. Expand