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Serine/Arginine-Rich Splicing Factor 2

Known as: Protein PR264, SRSF2, Splicing Factor SC35 
Serine/arginine-rich splicing factor 2 (221 aa, ~25 kDa) is encoded by the human SRSF2 gene. This protein plays a role in the modulation of mRNA… 
National Institutes of Health

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Cell NucleusLigand BindingRNA BindingRNA Recognition Motif

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Screening for ASXL1 and SRSF2 mutations is imperative for treatment decision‐making in otherwise low or intermediate‐1 risk patients with myelofibrosis
Chapuy, B., Roemer, M.G., Stewart, C., Tan, Y., Abo, R.P., Zhang, L., Dunford, A.J., Meredith, D.M., Thorner, A.R., Jordanova, E… 
2018
2018
Isocitrate dehydrogenase 2 mutations correlate with leukemic transformation and are predicted by 2-hydroxyglutarate in myelodysplastic syndromes
PurposeThe myelodysplastic syndromes (MDS) are a group of hematologic disorders characterized by the presence of somatically… 
2017
2017
Altered EZH2 splicing and expression is associated with impaired histone H3 lysine 27 tri-Methylation in myelodysplastic syndrome.
Review
2016
Review
2016
Spectrum of complex chromosomal aberrations in a myelodysplastic syndrome and a brief review.
Myelodysplastic syndrome (MDS) is a heterogeneous premalignant condition characterized by cytopenia, ineffective hematopoiesis… 
2016
2016
The prognostic implication of SRSF2 mutations in Chinese patients with acute myeloid leukemia
Recently, somatic mutations in SRSF2 gene have been discovered in a proportion of hematologic malignancies including acute… 
2015
2015
Preferential occurrence of spliceosome mutations in acute myeloid leukemia with preceding myelodysplastic syndrome and/or myelodysplasia morphology
Spliceosome mutations are associated with myelodysplasia. Here, we aimed to evaluate the frequency and clinical associations of… 
2013
2013
SRSF2 mutation is present in the hypercellular and prefibrotic stage of primary myelofibrosis.
To the editor: Myeloproliferative neoplasms (MPNs) are characterized by their propensity to progress from overproduction of 1 or… 
Review
2013
Review
2013
Chronic myelomonocytic leukemia: myelodysplastic or myeloproliferative?
2011
2011
SRSF2 is required for sodium butyrate-mediated p21WAF1 induction and premature senescence in human lung carcinoma cell lines
Sodium butyrate (NaBu) is a histone deacetylase inhibitor that exhibits numerous antiproliferative activities in various cancer… 
2004
2004
Aging and Vitamin E Deficiency Are Responsible for Altered RNA Pathways
Abstract: Fibrillar centers (FCs), dense fibrillar (DFC) and granular (GC) components in nucleoli, and perichromatin granules… 
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