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International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma
TLDR
This new adenocarcinoma classification is needed to provide uniform terminology and diagnostic criteria, especially for bronchioloalveolar carcinoma (BAC), the overall approach to small nonresection cancer specimens, and for multidisciplinary strategic management of tissue for molecular and immunohistochemical studies. Expand
Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer
TLDR
This study implicates histone modification as a major feature of SCLC, reveals potentially therapeutically tractable genomic alterations and provides a generalizable framework for the identification of biologically relevant genes in the context of high mutational background. Expand
Frequent and Focal FGFR1 Amplification Associates with Therapeutically Tractable FGFR1 Dependency in Squamous Cell Lung Cancer
TLDR
F focal FGFR1 amplification is common in squamous cell lung cancer and associated with tumor growth and survival, suggesting that FGFR inhibitors may be a viable therapeutic option in this cohort of patients. Expand
Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer.
TLDR
Findings suggest that gain-of-function mutations in DDR2 are important oncogenic events and are amenable to therapy with dasatinib, and provide a rationale for designing clinical trials with the FDA-approved drug d asatinib in patients with lung SCCs. Expand
Ectopic Activation of Germline and Placental Genes Identifies Aggressive Metastasis-Prone Lung Cancers
TLDR
An ectopic gene expression signature associated with a subset of highly aggressive tumors, which predicted poor prognosis independently of the TNM (tumor size, node positivity, and metastasis) stage or histological subtype is identified. Expand
American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. This joint statement of the American
TLDR
The Diagnostic Process Is Dynamic Clinical Evaluation Radiological Evaluation Role of Surgical Lung Biopsy Unclassifiable Interstitial Pneumonia Bronchoalveolar Lavage Fluid Evaluation Idiopathic Pulmonary Fibrosis. Expand
In situ apoptotic cell labeling by the TUNEL method: improvement and evaluation on cell preparations.
TLDR
The results showed that with an adequate pretreatment, reliable TUNEL can be obtained after each fixative tested, and the existence of a limited population of intensely TUNel-positive cells that lacked apoptotic morphology contributes to the current debate about a preapoptotic state. Expand
E2F1 controls alternative splicing pattern of genes involved in apoptosis through upregulation of the splicing factor SC35
TLDR
It is demonstrated that E2F1 controls pre-mRNA processing events to induce apoptosis and the SC35 SR protein is identified as a key direct E 2F1-target in this setting. Expand
Apoptosis-related factors p53, Bcl2, and Bax in neuroendocrine lung tumors.
TLDR
The results suggest that aggressiveness in NE lung tumors could be linked, in addition to proliferation, to apoptosis-related factors. Expand
CD74-NRG1 fusions in lung adenocarcinoma.
TLDR
CD74-NRG1 gene fusions are activating genomic alterations in invasive mucinous adenocarcinomas and may offer a therapeutic opportunity for a lung tumor subtype with, so far, no effective treatment. Expand
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