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4 CLINICAL PARTICULARS 4.1 Therapeutic Indications Trimetazidine is indicated in adults as add-on therapy for the symptomatic… Expand Thalidomide Teratogenicity Target In the late 1950s and early 1960s, thalidomide was prescribed to pregnant women as a cure for… Expand Respiratory depression limits the use of opioid analgesia. Although well described clinically, the specific mechanisms of opioid… Expand Therapeutic regimens that comprise more than one active ingredient are commonly used in clinical medicine. Despite this, most… Expand GABAA (γ-aminobutyric acid type A) receptors mediate most of the 'fast' synaptic inhibition in the mammalian brain and are… Expand CONTEXT
Goal-directed delivery of sedative and analgesic medications is recommended as standard care in intensive care units… Expand GABAA (γ-aminobutyric acidA) receptors are molecular substrates for the regulation of vigilance, anxiety, muscle tension… Expand Thalidomide is a potent teratogen causing dysmelia (stunted limb growth) in humans. We have demonstrated that orally administered… Expand Fragrance compounds and essential oils with sedative effects influence the motility of mice in inhalation studies under… Expand To study risk factors for falling, we conducted a one-year prospective investigation, using a sample of 336 persons at least 75… Expand