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Safrole

Known as: Safroles, Allylcatechol Methylene Ether, 1,3-Benzodioxole, 5-(2-propenyl)- 
A naturally-occurring, colorless to slightly yellow liquid that is soluble in ethanol, ether, and chloroform. Safrole is no longer used in the United… 
National Institutes of Health

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17 relations

Narrower (9)

1'-acetoxysafrole1'-hydroxysafrole1'-oxosafrole1'-sulfoxysafrole
1,3-benzodioxoleIn Bloodagonistsanalogs & derivatives

Papers overview

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1985
1985
Ligand-complex formation between cytochromes P-450 and P-448 and methylenedioxyphenyl compounds.
The formation of ligand complexes between hepatic microsomal cytochrome P-450 and safrole, isosafrole and other… 
1981
1981
Biology of hepatocellular neoplasia in the mouse. II. Sequential enzyme histochemical analysis of BALB/c mouse liver during safrole-induced carcinogenesis.
Sequential alterations in enzyme histochemical profiles and reaction of hepatocytes to rapid iron overload were examined in male… 
Review
1981
Review
1981
Carcinogens occurring naturally in food.
Carcinogens naturally occurring in food include metabolites of microorganisms which infect plants during harvesting and storage… 
1980
1980
Ligand binding of safrole to cytochrome P-450.
Safrole, a hepatocarcinogen, is converted by the microsomal mono-oxygenase system to a reactive intermediate which interacts with… 
Highly Cited
1976
Highly Cited
1976
Dietary constituents altering the responses to chemical carcinogens.
This paper deals with two categories of compounds having the capacity to inhibit the neoplastic effects of chemical carcinogens… 
1972
1972
Effects of safrole and isosafrole pretreatment on N- and ring-hydroxylation of 2-acetamidofluorene by the rat and hamster.
1. The effects of safrole and isosafrole pretreatment on both N- and ring-hydroxylation of 2-acetamidofluorene were studied in… 
1972
1972
Interaction of safrole and isosafrole with hepatic microsomal haemoproteins.
Safrole and isosafrole are known inducers of the liver microsomal drug-metabolizing enzymes of the rat (Parke & Rahman, 1970) and… 
1971
1971
Induction of a new hepatic microsomal haemoprotein by safrole and isosafrole.
overall toxicity of repeated doses of 40, 30 and 20 mg of diethylnitrosamine/kg, as manifested by faster growth rate and… 
1964
1964
INVESTIGATION OF EGYPTIAN BASIL ESSENTIAL OILS BY SIMPLE CHROMATOGRAPHIC METHOD.
Two kinds of basil oil are produced in Egypt under the so-called white and red basil oils. The present study reveals the… 
1961
1961
Toxic and possible carcinogenic effects of 4-allyl-1,2-methylenedioxybenzene (Safrole) in rats on deficient diets.
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