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A new series of tacrine-multialkoxybenzene hybrids (9a-9n) were designed, synthesized and evaluated as dual inhibitors of… Expand Podophyllotoxin has been extensively used as a lead agent in the development of new anticancer drugs. On the basis of the… Expand In the scope of a research program aiming at the synthesis and pharmacological evaluation of novel possible antitumour prototype… Expand Significant progress has been made in the direct arylation of simple arenes. A number of catalyst systems have been developed… Expand Two series of 5 and 6-substituted 1,3-benzodioxole peptidyl derivatives were synthesized and evaluated as antitumour and… Expand Publisher Summary This chapter discusses the cytochrome P450 metabolic intermediate (MI) complexes from macrolide antibiotics and… Expand Since mutagenic substances induce structural changes in DNA, studies were undertaken to determine whether substances would modify… Expand Abstract The epoxidation of aldrin by microsomal preparations from houseflies and pig liver was markedly inhibited by a number of… Expand Abstract Dihydrosafrole on chronic feeding produced benign and malignant esophageal tumors. Safrole is a hepatic carcinogen… Expand Summary The toxicity in the rat of a number of allyl, propenyl, propyl, and related compounds has been compared using as criteria… Expand