A novel potent vasoconstrictor peptide produced by vascular endothelial cells
- M. Yanagisawa, H. Kurihara, T. Masaki
- Biology, ChemistryNature
- 31 March 1988
Cloning and sequencing of preproendothelin complementary DNA shows that mature endothelin is generated through an unusual proteolytic processing, and regional homologies to a group of neurotoxins suggest that endothelins is an endogenous modulator of voltage-dependent ion channels.
Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor
- T. Sakurai, M. Yanagisawa, T. Masaki
- Biology, ChemistryNature
- 20 December 1990
The cloning of a complementary DNA encoding one subtype belonging to the superf amily of G protein-coupled receptors is reported, indicating that this cDNA encodes a 'nonselective' subtype of the receptor which is different from the vascular smooth muscle receptor.
The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.
- A. Inoue, M. Yanagisawa, T. Masaki
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 1 April 1989
Three distinct human endothelin-related genes were cloned by screening a genomic DNA library under a low hybridization stringency with a synthetic oligonucleotide probe encoding a portion of the endotheli sequence, suggesting the possible existence of endothelins receptor subtypes.
Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity
- J. Hara, C. Beuckmann, T. Sakurai
- Biology, PsychologyNeuron
- 1 May 2001
Hypothalamic Orexin Neurons Regulate Arousal According to Energy Balance in Mice
- A. Yamanaka, C. Beuckmann, T. Sakurai
- Biology, PsychologyNeuron
- 5 June 2003
Distribution of orexin neurons in the adult rat brain 1 Published on the World Wide Web on 17 March 1999. 1
- Tadahiro Nambu, T. Sakurai, K. Mizukami, Y. Hosoya, M. Yanagisawa, K. Goto
- BiologyBrain Research
- 1 May 1999
Input of Orexin/Hypocretin Neurons Revealed by a Genetically Encoded Tracer in Mice
- T. Sakurai, Ruby Nagata, M. Yanagisawa
- Biology, PsychologyNeuron
- 2 June 2005
Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system 1 1 Published on the World Wide Web on 27 June 2000.
- Toshiaki Nakamura, K. Uramura, T. Sakurai
- Biology, PsychologyBrain Research
- 1 August 2000
Orexins activate histaminergic neurons via the orexin 2 receptor.
- A. Yamanaka, N. Tsujino, T. Sakurai
- Biology, PsychologyBiochemical and Biophysical Research…
- 1 February 2002
The physiological significance of histaminergic neurons in the orexin-induced arousal responses is shown, which strongly suggest that activation of histaminationergic neurons by orexins might be important for modulation of the arousal.
Input of Orexin/Hypocretin Neurons Revealed by a Genetically Encoded Tracer in Mice
- T. Sakurai, Ruby Nagata, M. Yanagisawa
- Biology, PsychologyNeuron
- 21 April 2005
...
...