A novel potent vasoconstrictor peptide produced by vascular endothelial cells
Cloning and sequencing of preproendothelin complementary DNA shows that mature endothelin is generated through an unusual proteolytic processing, and regional homologies to a group of neurotoxins suggest that endothelins is an endogenous modulator of voltage-dependent ion channels.
Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor
The cloning of a complementary DNA encoding one subtype belonging to the superf amily of G protein-coupled receptors is reported, indicating that this cDNA encodes a 'nonselective' subtype of the receptor which is different from the vascular smooth muscle receptor.
The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.
- A. Inoue, M. Yanagisawa, T. Masaki
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 1 April 1989
Three distinct human endothelin-related genes were cloned by screening a genomic DNA library under a low hybridization stringency with a synthetic oligonucleotide probe encoding a portion of the endotheli sequence, suggesting the possible existence of endothelins receptor subtypes.
Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity
Hypothalamic Orexin Neurons Regulate Arousal According to Energy Balance in Mice
Distribution of orexin neurons in the adult rat brain 1 Published on the World Wide Web on 17 March 1999. 1
Input of Orexin/Hypocretin Neurons Revealed by a Genetically Encoded Tracer in Mice
Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system 1 1 Published on the World Wide Web on 27 June 2000.
Orexins activate histaminergic neurons via the orexin 2 receptor.
- A. Yamanaka, N. Tsujino, T. Sakurai
- Biology, PsychologyBiochemical and Biophysical Research…
- 1 February 2002
The physiological significance of histaminergic neurons in the orexin-induced arousal responses is shown, which strongly suggest that activation of histaminationergic neurons by orexins might be important for modulation of the arousal.