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Prevention of cytotoxicity and inhibition of intercellular communication by antioxidant catechins isolated from Chinese green tea.
TLDR
An antioxidant fraction of Chinese green tea, containing several catechins, has been previously shown to inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced tumor promotion in mouse skin and was shown to have antioxidative activity toward hydrogen peroxide and the superoxide radical.
The role of oxidative stress in carcinogenesis.
TLDR
This review examines the evidence of cellular oxidants' involvement in the carcinogenesis process, and focuses on the mechanisms for production, cellular damage produced, and the role of signaling cascades by reactive oxygen species.
PPARα Agonist-Induced Rodent Tumors: Modes of Action and Human Relevance
TLDR
An in-depth analysis of the state of the science on several topics critical to evaluating the relationship between the MOA for PPARα agonists and the human relevance of related animal tumors produces a range of outcomes, depending partly on the quality and quantity of MOA data available from laboratory animals and related information from human data sources.
Oxidative Stress and Oxidative Damage in Carcinogenesis
TLDR
Evidence demonstrates an association between a number of single nucleotide polymorphisms in oxidative DNA repair genes and antioxidant genes with human cancer susceptibility and the resultant altered gene expression patterns evoked by ROS contribute to the carcinogenesis process.
PPARalpha agonist-induced rodent tumors: modes of action and human relevance.
TLDR
An in-depth analysis of the state of the science on several topics critical to evaluating the relationship between the MOA for PPARalpha agonists and the human relevance of related animal tumors is provided.
Mode of action in relevance of rodent liver tumors to human cancer risk.
TLDR
It was concluded that the induction of rodent liver tumors by porphyrogenic compounds followed a cytotoxic MOA, and that liver tumors formed as a result of sustained cytotoxicity and regenerative proliferation are considered relevant for evaluating human cancer risk if appropriate metabolism occurs in the animal models and in humans.
The role of oxidative stress in chemical carcinogenesis.
TLDR
A potential role for oxidative-induced injury in the cancer process specifically during the promotion stage is supported and the effect of nongenotoxic carcinogens may be amplified in rodents but not in primates because of rodents' greater sensitivity to ROS.
Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis.
TLDR
The data presented in this symposium illustrate to the toxicologist the central role played by Kupffer cells in mediating hepatotoxicity.
Alterations in brain structure and function in breast cancer survivors: effect of post-chemotherapy interval and relation to oxidative DNA damage
TLDR
This is the first study to show structural and functional effects of PCI and to relate oxidativeDNA damage to brain alterations in BCS and the relationship with oxidative DNA damage provides a mechanistic clue warranting further investigation.
Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework.
TLDR
This article offers a set of recommendations that scientists believe can achieve greater conceptual harmony in dose-response terminology, as well as better understanding and communication across the broad spectrum of biological disciplines.
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