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SUV39H1 gene

Known as: Suppressor of variegation 3-9 homolog 1 (Drosophila) Gene, SUPPRESSOR OF VARIEGATION 3-9, DROSOPHILA, HOMOLOG OF, 1, KMT1A 
This gene is involved in epigenetic control of gene expression.
National Institutes of Health

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Gene ExpressionMethylationProtein methylationSUV39H1 protein, human

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SUV39H1 wt Allele

Papers overview

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2018
2018
Epigenetic silenced miR‐125a‐5p could be self‐activated through targeting Suv39H1 in gastric cancer
Emerging evidence suggests that microRNAs (miRNAs) serve an important role in tumorigenesis and development. Although the low… 
2018
2018
Functional Role of SUV39H1 in Human Renal Tubular Epithelial Cells Under High-glucose Ambiance
SUV39H1, the histone methyltransferase (HMTase) of histone H3 lysine 9 trimethylation (H3K9me3), is a known transcriptional… 
2017
2017
Aberrant levels of SUV39H1 and SUV39H2 methyltransferase are associated with genomic instability in chronic lymphocytic leukemia
Chromosomal alterations are commonly detected in patients with chronic lymphocytic leukemia (CLL) and impact disease pathogenesis… 
2016
2016
Histone H2AK119 and H2BK120 mono-ubiquitination modulate SET7/9 and SUV39H1 in type 1 diabetes-induced renal fibrosis.
Hyperglycaemia-induced expression of extracellular matrix (ECM) components plays a major role in the development of diabetic… 
2015
2015
Identification of epipolythiodioxopiperazines HDN-1 and chaetocin as novel inhibitor of heat shock protein 90
The molecular chaperone heat shock protein 90 (Hsp90) has emerged as an important target for cancer treatment. HDN-1, an… 
2014
2014
Involvement of EZH2, SUV39H1, G9a and associated molecules in pathogenesis of urethane induced mouse lung tumors: potential targets for cancer control.
2013
2013
The Histone Methyltransferase SUV39H1 Suppresses Embryonal Rhabdomyosarcoma Formation in Zebrafish
Epigenetics, or the reversible and heritable marks of gene regulation not including DNA sequence, encompasses chromatin… 
2009
2009
The p38 MAPK family, a pushmi-pullyu of skeletal muscle differentiation
In this issue, Gillespie et al. (Gillespie et al. 2009. J. Cell Biol. doi:10.1083/jcb.200907037) demonstrate that the mitogen… 
2008
2008
Messenger RNA expression patterns of histone‐associated genes in bovine preimplantation embryos derived from different origins
Histone modification genes in bovine embryos: The mRNA expression pattern of histone‐related genes was determined in bovine… 
2007
2007
Cabin1 Represses MEF2 Transcriptional Activity by Association with a Methyltransferase, SUV39H1*
Myocyte enhancer factor 2 (MEF2) plays pivotal roles in various biological processes, and its transcriptional activity is… 
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