Epigenetic silenced miR‐125a‐5p could be self‐activated through targeting Suv39H1 in gastric cancer

@inproceedings{Cai2018EpigeneticSM,
  title={Epigenetic silenced miR‐125a‐5p could be self‐activated through targeting Suv39H1 in gastric cancer},
  author={Mingzhi Cai and Qiuxian Chen and Juntao Shen and Chenbing Lv and Lisheng Cai},
  booktitle={Journal of cellular and molecular medicine},
  year={2018}
}
Emerging evidence suggests that microRNAs (miRNAs) serve an important role in tumorigenesis and development. Although the low expression of miR-125a-5p in gastric cancer has been reported, the underlying mechanism remains unknown. In the current study, the low expression of miR-125a-5p in gastric cancer was verified in paired cancer tissues and adjacent non-tumour tissues. Furthermore, the GC islands in the miR-125a-5p region were hypermethylated in the tumour tissues. And the hypermethylation… CONTINUE READING

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