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SR 4233

Known as: SR-4233, SR4233 
National Institutes of Health

Related topics

Related topics

2 relations
Tirazone

Broader (1)

tirapazamine

Papers overview

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2003
2003
Non-nuclear localized human NOSII enhances the bioactivation and toxicity of tirapazamine (SR4233) in vitro.
Tirapazamine (TPZ) is the lead member of a class of bioreductive drugs currently in phase II and III clinical trials. TPZ… 
Highly Cited
2001
Highly Cited
2001
Metabolism of tirapazamine by multiple reductases in the nucleus.
2001
2001
Optimizing the use of combined radioimmunotherapy and hypoxic cytotoxin therapy as a function of tumor hypoxia
Combined radioimmunotherapy (RAIT) and hypoxic cytotoxin therapy (SR4233 or NLCQ‐1) have been evaluated with both modalities… 
1999
1999
DNA damage measured by the comet assay in head and neck cancer patients treated with tirapazamine.
Tirapazamine (TPZ) [3-amino-1,2,4-benzotriazine 1,4-dioxide, SR4233, WIN 59075, and Tirazone] is a novel anticancer drug that is… 
1996
1996
Efficacy of agents counteracting hypoxia in fractionated radiation regimes.
1994
1994
The effect of low pH and hypoxia on the cytotoxic effects of SR4233 and mitomycin C in vitro.
Highly Cited
1992
Highly Cited
1992
Enhancement of alkylating agent activity by SR-4233 in the FSaIIC murine fibrosarcoma.
BACKGROUND The most commonly used antineoplastic drugs are more cytotoxic toward normally oxygenated tumor cells than toward… 
1990
1990
Reductive metabolism of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233) and the induction of unscheduled DNA synthesis in rat and human derived cell lines.
The cellular and microsomal reductive metabolism of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233) was studied aerobically and… 
1990
1990
DNA damaging effects and voltammetric studies on the hypoxic cell toxin 3-amino-1,2,4-benzotriazine-1,4-dioxide, SR4233, as a function of pH.
Highly Cited
1989
Highly Cited
1989
The differential hypoxic cytotoxicity of bioreductive agents determined in vitro by the MTT assay.
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