tirapazamine

Known as: 1,2,4-Benzotriazin-3-amine, 1,4-dioxide, 3-Amino-1,2,4-benzotriazine 1,4-dioxide, 3-Amino-1,2,4-benzotriazine-1,4-dioxide 
A benzotriazine di-N-oxide with potential antineoplastic activity. Tirapazamine is selectively activated by multiple reductases to form free radicals… (More)
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Culture of cells as three-dimensional (3D) aggregates can enhance in vitro tests for basic biological research as well as for… (More)
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Highly Cited
2010
Highly Cited
2010
PURPOSE Promising results in a randomized phase II trial with the hypoxic cytotoxin tirapazamine (TPZ) combined with cisplatin… (More)
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Highly Cited
2010
Highly Cited
2010
PURPOSE To determine the prognostic importance of p16 and human papillomavirus (HPV) in patients with oropharyngeal cancer… (More)
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Highly Cited
2007
Highly Cited
2007
The interaction of stem cells with their bone marrow microenvironment is a critical process in maintaining normal hematopoiesis… (More)
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2007
2007
UNLABELLED We evaluated the predictive value of PET using the hypoxia tracer (18)F-fluoroazomycin arabinoside ((18)F-FAZA) for… (More)
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Highly Cited
2006
Highly Cited
2006
PURPOSE To determine the association between tumor hypoxia, treatment regimen, and locoregional failure (LRF) in patients with… (More)
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Highly Cited
2005
Highly Cited
2005
PURPOSE To select one of two chemoradiotherapy regimens for locally advanced squamous cell carcinoma (SCC) of the head and neck… (More)
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2002
2002
Tirapazamine (TPZ), a hypoxia-selective cytotoxin, has demonstrated activity in cancer clinical trials. Under hypoxic conditions… (More)
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Highly Cited
2000
Highly Cited
2000
PURPOSE A phase III trial, Cisplatin and Tirapazamine in Subjects with Advanced Previously Untreated Non-Small-Cell Lung Tumors… (More)
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1998
1998
PURPOSE Hypoxia-selective cytotoxic agents, like tirapazamine (TPZ), must diffuse considerable distances in tumors to reach their… (More)
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