Genotoxic potential of tamoxifen and analogues in female Fischer F344/n rats, DBA/2 and C57BL/6 mice and in human MCL-5 cells.
- I. White, F. De Matteis, D. Phillips
- Biology, MedicineCarcinogenesis
- 1 December 1992
Tamoxifen induced a significant increase in micronucleus formation in a dose dependent manner in cultures of MCL-5 cells, a human cell line that expresses 5 different human cytochrome P450 isoenzymes, as well as epoxide hydrolase.
Adenomyosis--a result of disordered stromal differentiation.
- E. Parrott, M. Butterworth, A. Green, I. White, P. Greaves
- Biology, MedicineAmerican Journal of Pathology
- 1 August 2001
Tamoxifen DNA damage detected in human endometrium using accelerator mass spectrometry.
It is demonstrated that after oral administration, tamoxifen forms adducts in human uterine DNA but at low numbers relative to those previously reported in women after long-term tamoxIFen treatment where levels, when detected, ranged from 15000 to 130000 adducted nucleotides.
Tamoxifen induces endometrial and vaginal cancer in rats in the absence of endometrial hyperplasia.
- P. Carthew, R. E. Edwards, M. Tucker
- Medicine, BiologyCarcinogenesis
- 1 April 2000
There was a significant increase in the incidence of uterine adenocarcinomas and a 9% incidence of squamous cell carcinomas of the vagina/cervix in the absence of any oestrogen agonist effect in the uterus between 24 and 35 months after tamoxifen treatment.
The conversion of pyrrolizidine alkaloids to N-oxides and to dihydropyrrolizine derivatives by rat-liver microsomes in vitro.
- A. Mattocks, I. White
- Chemistry, BiologyChemico-Biological Interactions
- 1 October 1971
Genotoxicity of tamoxifen, tamoxifen epoxide and toremifene in human lymphoblastoid cells containing human cytochrome P450s.
- J. Styles, A. Davies, L. L. Smith
- Biology, MedicineCarcinogenesis
- 1994
The positive clastogenic effects elicited in lymphoblastoid cells by tamoxifen epoxide suggest that the genotoxic (and possibly the carcinogenic) effects of tamoxIFen may be due to one or more epoxide metabolites that are generated intracellularly, probably in close proximity to the nucleus.
The relationship between brain levels of cismethrin and bioresmethrin in female rats and neurotoxic effects
- I. White, R. Verschoyle, M. Moradian, J. Barnes
- Biology
- 1 October 1976
Pyrrolic metabolites from non-toxic pyrrolizidine alkaloids.
- A. Mattocks, I. White
- ChemistryNature: New biology
- 26 May 1971
THERE is evidence that some or all of the cytotoxic effects of unsaturated pyrrolizidine alkaloids are, in some animals, caused by pyrrolic metabolites formed by enzymatic dehydro-genation of the…
Induction of CYP2B1 and 3A1, and associated monoxygenase activities by tamoxifen and certain analogues in the livers of female rats and mice.
- I. White, A. Davies, L. L. Smith, S. Dawson, F. De Matteis
- Biology, MedicineBiochemical Pharmacology
- 7 January 1993
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