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SPI1 gene

Known as: SPI-A, SFFV VIRUS-INDUCED MURINE ERYTHROLEUKEMIA ONCOGENE, MOUSE, HOMOLOG OF, SPLEEN FOCUS FORMING VIRUS PROVIRAL INTEGRATION ONCOGENE SPI1 
SPI1 is an oncogene specifically activated in acute murine erythroleukemias, induced by the Friend spleen focus forming virus. It encodes the… 
National Institutes of Health

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Related topics

11 relations
11p11.2Acute Erythroblastic LeukemiaCell Differentiation processHomo sapiens

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SPI1 wt Allele

Papers overview

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Highly Cited
2012
Highly Cited
2012
Direct interaction of PU.1 with oncogenic transcription factors reduces its serine phosphorylation and promoter binding
Highly Cited
2005
Highly Cited
2005
Mutations of the PU.1 Ets domain are specifically associated with murine radiation-induced, but not human therapy-related, acute myeloid leukaemia
Murine radiation-induced acute myeloid leukaemia (AML) is characterized by loss of one copy of chromosome 2. Previously, we… 
Review
2004
Review
2004
Regulation of Osteoclast Formation and Function*
The human skeleton is continuously remodeling during growth and in response to mechanical stress and hormonal regulation. The… 
2004
2004
Combination of retinoic acid and tumor necrosis factor overcomes the maturation block in a variety of retinoic acid-resistant acute promyelocytic leukemia cells.
Retinoic acid (RA) overcomes the maturation block in t(15:17) acute promyelocytic leukemia (APL), leading to granulocytic… 
Highly Cited
2001
Highly Cited
2001
Evolution of hematopoiesis: Three members of the PU.1 transcription factor family in a cartilaginous fish, Raja eglanteria.
T lymphocytes and B lymphocytes are present in jawed vertebrates, including cartilaginous fishes, but not in jawless vertebrates… 
2001
2001
Lineage switch induced by overexpression of Ets family transcription factor PU.1 in murine erythroleukemia cells.
PU.1 is an Ets family transcription factor essential for myelomonocyte and B-cell development. We previously showed that… 
Highly Cited
2000
Highly Cited
2000
Cooperation Among Stat1, Glucocorticoid Receptor, and PU.1 in Transcriptional Activation of the High-Affinity Fcγ Receptor I in Monocytes1
IFN-γ and glucocorticoids regulate inflammatory and immune responses through Stat1 and glucocorticoid receptor (GR) transcription… 
Highly Cited
1997
Highly Cited
1997
Granulocytic differentiation of normal hematopoietic precursor cells induced by transcription factor PU.1 correlates with negative regulation of the c-myb promoter.
Numerous transcription factors allow hematopoietic cells to respond to lineage- and stage-specific cytokines and/or to act as… 
1995
1995
IFN-gamma and lipopolysaccharide induce DNA binding of transcription factor PU.1 in murine tissue macrophages.
The transcription factor PU.1, the Spi-1 oncogene product, is found principally in B cells and macrophages. PU.1 binds to a… 
Highly Cited
1990
Highly Cited
1990
The PU.1 transcription factor is the product of the putative oncogene Spi-1
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