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SPI1 gene

Known as: SPI-A, SFFV VIRUS-INDUCED MURINE ERYTHROLEUKEMIA ONCOGENE, MOUSE, HOMOLOG OF, SPLEEN FOCUS FORMING VIRUS PROVIRAL INTEGRATION ONCOGENE SPI1 
SPI1 is an oncogene specifically activated in acute murine erythroleukemias, induced by the Friend spleen focus forming virus. It encodes the… 
National Institutes of Health

Related topics

Related topics

11 relations
11p11.2Acute Erythroblastic LeukemiaCell Differentiation processHomo sapiens

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SPI1 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
T cells: IL-9 breaks down barriers
Interleukin-9 secreted by T helper 9 cells impairs intestinal barrier function and exacerbates ulcerative colitis. 
Highly Cited
2012
Highly Cited
2012
Dynamic Transformations of Genome-wide Epigenetic Marking and Transcriptional Control Establish T Cell Identity
Highly Cited
2008
Highly Cited
2008
PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis
Both PU.1 (also called SFPI1), an Ets-family transcription factor, and AML1 (also called RUNX1), a DNA-binding subunit of the CBF… 
Highly Cited
2003
Highly Cited
2003
The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia.
The transcription factor PU.1 plays a pivotal role in normal myeloid differentiation. PU.1(-/-) mice exhibit a complete block in… 
Highly Cited
2002
Highly Cited
2002
PU.1 regulates expression of the interleukin-7 receptor in lymphoid progenitors.
Highly Cited
1999
Highly Cited
1999
Precise developmental regulation of Ets family transcription factors during specification and commitment to the T cell lineage.
Ets family transcription factors control the expression of a large number of genes in hematopoietic cells. Here we show… 
Highly Cited
1997
Highly Cited
1997
PU.1 functions in a cell-autonomous manner to control the differentiation of multipotential lymphoid-myeloid progenitors.
Highly Cited
1996
Highly Cited
1996
PU.1 (Spi-1) and C/EBP alpha regulate the granulocyte colony-stimulating factor receptor promoter in myeloid cells.
Cytokines, important for lineage commitment and differentiation during hematopoiesis, exert their influence by binding specific… 
Highly Cited
1996
Highly Cited
1996
Pip, a lymphoid-restricted IRF, contains a regulatory domain that is important for autoinhibition and ternary complex formation with the Ets factor PU.1.
Pip is a lymphoid-restricted IRF transcription factor that is recruited to composite elements within immunoglobulin light-chain… 
Highly Cited
1995
Highly Cited
1995
Epstein-Barr virus nuclear protein 2 transactivation of the latent membrane protein 1 promoter is mediated by J kappa and PU.1
Expression of the Epstein-Barr virus (EBV) latent membrane protein 1 (LMP-1) oncogene is regulated by the EBV nuclear protein 2… 
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