SPI1 wt Allele

Known as: PU.1, SFPI1, SPI1 
The human SPI1 wild-type allele is located in the vicinity of 11p11.2 and is approximately 24 kb in length. This allele, which encodes transcription… (More)
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
OBJECTIVE The transcription factor PU.1 (encoded by Sfpi1) promotes myeloid differentiation, but it is unclear what downstream… (More)
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Highly Cited
2009
Highly Cited
2009
Tissue macrophages comprise a heterogeneous group of cell types differing in location, surface markers and function. Red pulp… (More)
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Highly Cited
2006
Highly Cited
2006
Tightly regulated expression of the transcription factor PU.1 is crucial for normal hematopoiesis. PU.1 knockdown mice develop… (More)
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Highly Cited
2004
Highly Cited
2004
PU.1 is a member of the Ets family of transcription factors and plays an essential role in the development of both myeloid and… (More)
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Highly Cited
2000
Highly Cited
2000
The GATA-1 transcription factor is capable of suppressing the myeloid gene expression program when ectopically expressed in… (More)
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Highly Cited
1999
Highly Cited
1999
Malignant transformation usually inhibits terminal cell differentiation but the precise mechanisms involved are not understood… (More)
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Highly Cited
1997
Highly Cited
1997
Transcription factor PU.1 is required for the development of lymphoid and myeloid progenitors during fetal hematopoiesis. By… (More)
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Highly Cited
1996
Highly Cited
1996
Pip is a lymphoid-restricted IRF transcription factor that is recruited to composite elements within immunoglobulin light-chain… (More)
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Highly Cited
1996
Highly Cited
1996
Insertional mutagenesis of the spi-1 gene is associated with the emergence of malignant proerythroblasts during Friend virus… (More)
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Highly Cited
1988
Highly Cited
1988
Retroviral insertional mutagenesis has been proposed as an efficient mechanism to turn on or to increase the expression of… (More)
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