• Publications
  • Influence
The IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue Virus
Influenza viruses exploit host cell machinery to replicate, resulting in epidemics of respiratory illness. In turn, the host expresses antiviral restriction factors to defend against infection. ToExpand
  • 911
  • 81
Meta- and Orthogonal Integration of Influenza "OMICs" Data Defines a Role for UBR4 in Virus Budding.
Several systems-level datasets designed to dissect host-pathogen interactions during influenza A infection have been reported. However, apparent discordance among these data has hampered their fullExpand
  • 581
  • 41
IFITM3 restricts the morbidity and mortality associated with influenza
The 2009 H1N1 influenza pandemic showed the speed with which a novel respiratory virus can spread and the ability of a generally mild infection to induce severe morbidity and mortality in a subset ofExpand
  • 498
  • 38
Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen
HIV-1 exploits multiple host proteins during infection. We performed a large-scale small interfering RNA screen to identify host factors required by HIV-1 and identified more than 250 HIV-dependencyExpand
  • 1,013
  • 35
Distinct Patterns of IFITM-Mediated Restriction of Filoviruses, SARS Coronavirus, and Influenza A Virus
Interferon-inducible transmembrane proteins 1, 2, and 3 (IFITM1, 2, and 3) are recently identified viral restriction factors that inhibit infection mediated by the influenza A virus (IAV)Expand
  • 340
  • 34
RNA interference screen for human genes associated with West Nile virus infection
West Nile virus (WNV), and related flaviviruses such as tick-borne encephalitis, Japanese encephalitis, yellow fever and dengue viruses, constitute a significant global human health problem. However,Expand
  • 469
  • 34
A genome-wide genetic screen for host factors required for hepatitis C virus propagation
  • Q. Li, A. Brass, +4 authors S. Elledge
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences
  • 22 September 2009
Hepatitis C virus (HCV) infection is a major cause of end-stage liver disease and a leading indication for liver transplantation. Current therapy fails in many instances and is associated withExpand
  • 344
  • 21
The CD225 Domain of IFITM3 Is Required for both IFITM Protein Association and Inhibition of Influenza A Virus and Dengue Virus Replication
ABSTRACT The interferon-induced transmembrane protein 3 (IFITM3) gene is an interferon-stimulated gene that inhibits the replication of multiple pathogenic viruses in vitro and in vivo. IFITM3 is aExpand
  • 105
  • 20
IFITM3 Inhibits Influenza A Virus Infection by Preventing Cytosolic Entry
To replicate, viruses must gain access to the host cell's resources. Interferon (IFN) regulates the actions of a large complement of interferon effector genes (IEGs) that prevent viral replication.Expand
  • 255
  • 18
Crystal structure of PU.1/IRF-4/DNA ternary complex.
The Ets and IRF transcription factor families contain structurally divergent members, PU.1, Spi-B and IRF-4 (Pip), IRF-8 (ICSBP), respectively, which have evolved to cooperatively assemble onExpand
  • 140
  • 18