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SPDEF gene

Known as: SAM POINTED DOMAIN-CONTAINING ETS TRANSCRIPTION FACTOR, PROSTATE EPITHELIUM-SPECIFIC ETS TRANSCRIPTION FACTOR, PDEF 
This gene may be involved in prostate development and prostate cancer.
National Institutes of Health

Related topics

Related topics

5 relations
Cell Fate ControlHomo sapiensSAM Pointed Domain-Containing Ets Transcription FactorTranscriptional Regulation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Examination of methylation changes of VIM, CXCR4, DOK7, and SPDEF genes in peripheral blood DNA in breast cancer patients.
BACKGROUND Studying whole blood DNA methylation as a risk marker has valuable applications in either diagnosis or staging of… 
2017
2017
Runx2, a novel regulator for goblet cell differentiation and asthma development
Airway goblet cell differentiation and related mucus overproduction are critical processes in the development of respiratory… 
2016
2016
Clarithromycin Suppresses Chloride Channel Accessory 1 and Inhibits Interleukin-13-Induced Goblet Cell Hyperplasia in Human Bronchial Epithelial Cells
ABSTRACT Activation of the interleukin-13 (IL-13) receptor leads to signal transducer and activator of transcription 6 (STAT6… 
2016
2016
The Histologic Classifications of Lung Adenocarcinomas Are Discriminable by Unique Lineage Backgrounds
Review
2011
Review
2011
Prostate derived ETS factor (PDEF): a putative tumor metastasis suppressor.
2010
2010
Protein Kinase CK2 Controls the Stability of Prostate Derived ETS Factor
Prostate Derived ETS Factor (PDEF) is an ETS transcription factor expressed in prostate epithelial cells, and diminished PDEF… 
2009
2009
PDEF is a negative regulator of colon cancer cell growth and migration
ETS is a family of transcriptional regulators with functions in most biological processes. Dysregulated ETS factor function leads… 
2009
2009
Proteomic analysis of a PDEF Ets transcription factor-interacting protein complex.
Ets proteins are a family of transcription factors that share an 85 amino acid conserved DNA binding domain, the ETS domain. The… 
Highly Cited
2005
Highly Cited
2005
Novel role for PDEF in epithelial cell migration and invasion.
Cell migration and invasion are two critical cellular processes that are often deregulated during tumorigenesis. To identify… 
2005
2005
Analysis of the 2.0 A crystal structure of the protein-DNA complex of the human PDEF Ets domain bound to the prostate specific antigen regulatory site.
PDEF, a prostate epithelial specific transcription factor, is a member of the Ets family of DNA binding proteins. Here we report… 
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