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SP1 gene

Known as: Sp1 transcription factor, TRANSCRIPTION FACTOR Sp1, Sp1 Transcription Factor Gene 
This gene plays a role in transcriptional regulation and is involved in several signal transduction pathways.
National Institutes of Health

Related topics

Related topics

5 relations
Homo sapiensSP1 wt AlleleSp1 Transcription FactorTranscriptional Regulation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
aPKC‐ι/P‐Sp1/Snail signaling induces epithelial–mesenchymal transition and immunosuppression in cholangiocarcinoma
Cholangiocarcinoma (CCA) is a highly malignant bile duct cancer that tends to invade and metastasize early. The epithelial… 
Highly Cited
2016
Highly Cited
2016
Nobiletin inhibits human osteosarcoma cells metastasis by blocking ERK and JNK-mediated MMPs expression
Nobiletin, a polymethoxyflavone, has a few pharmacological activities, including anti-inflammation and anti-cancer effects… 
Highly Cited
2014
Highly Cited
2014
O-GlcNAc modification of transcription factor Sp1 mediates hyperglycemia-induced VEGF-A upregulation in retinal cells.
PURPOSE Proangiogenic protein VEGF-A contributes significantly to retinal lesions and neovascularization in diabetic retinopathy… 
Highly Cited
2014
Highly Cited
2014
Infantile exposure to lead and late-age cognitive decline: Relevance to AD
Highly Cited
2014
Highly Cited
2014
Specificity Protein 1 (Sp1) Maintains Basal Epithelial Expression of the miR-200 Family
Background: Epithelial-mesenchymal transition (EMT) is a key process in embryonic development and cancer metastasis. Results: Sp1… 
Highly Cited
2012
Highly Cited
2012
Influenza A induces the major secreted airway mucin MUC5AC in a protease-EGFR-extracellular regulated kinase-Sp1-dependent pathway.
Mucins, the main glycoproteins present within mucus, modulate the rheologic properties of airways and participate in lung defense… 
Review
2012
Review
2012
Crosstalk of Sp1 and Stat3 signaling in pancreatic cancer pathogenesis.
Highly Cited
2008
Highly Cited
2008
Sumoylation of specificity protein 1 augments its degradation by changing the localization and increasing the specificity protein 1 proteolytic process.
Highly Cited
2005
Highly Cited
2005
Survivin enhances telomerase activity via up-regulation of specificity protein 1- and c-Myc-mediated human telomerase reverse transcriptase gene transcription.
Highly Cited
2004
Highly Cited
2004
Role of Sp Proteins in Regulation of Vascular Endothelial Growth Factor Expression and Proliferation of Pancreatic Cancer Cells
Sp proteins play an important role in angiogenesis and growth of cancer cells, and specificity protein 1 (Sp1) has been linked to… 
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