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SP1 gene

Known as: Sp1 transcription factor, TRANSCRIPTION FACTOR Sp1, Sp1 Transcription Factor Gene 
This gene plays a role in transcriptional regulation and is involved in several signal transduction pathways.
National Institutes of Health

Related topics

Related topics

5 relations
Homo sapiensSP1 wt AlleleSp1 Transcription FactorTranscriptional Regulation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
O-GlcNAc modification of Sp1 mediates hyperglycaemia-induced ICAM-1 up-regulation in endothelial cells.
2015
2015
Human retinal pigment epithelial cell proliferation by the combined stimulation of hydroquinone and advanced glycation end-products via up-regulation of VEGF gene
2014
2014
Reduced expression of 11β-hydroxysteroid dehydrogenase type 2 in preeclamptic placentas is associated with decreased PPARγ but increased PPARα expression.
Placental 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) is reduced in pregnancies complicated with preeclampsia (PE… 
2010
2010
Human Tyrosine Hydroxylase Natural Genetic Variation: Delineation of Functional Transcriptional Control Motifs Disrupted in the Proximal Promoter
Background—Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis. Common genetic variation at the… 
2009
2009
Tumor Necrosis Factor-α-mediated Regulation of the Inositol 1,4,5-Trisphosphate Receptor Promoter*
Tumor necrosis factor-α (TNF-α), a proinflammatory cytokine, has been implicated as a central mediator in multiple homeostatic… 
2007
2007
Specificity protein 1 and Smad-dependent regulation of human heme oxygenase-1 gene by transforming growth factor-beta1 in renal epithelial cells.
Excess transforming growth factor-beta1 (TGF-beta1) in the kidney leads to increased cell proliferation and deposition of… 
Highly Cited
2005
Highly Cited
2005
Survivin enhances telomerase activity via up-regulation of specificity protein 1- and c-Myc-mediated human telomerase reverse transcriptase gene transcription.
2002
2002
Direct physical interactions between HNF-4 and Sp1 mediate synergistic transactivation of the apolipoprotein CIII promoter.
We have investigated the mechanism of functional cooperativity between specificity protein 1 (Sp1) and hepatocyte nuclear factor… 
1999
1999
Mechanism of ubiquitous expression of mouse uncoupling protein 2 mRNA: control by cis-acting DNA element in 5'-flanking region.
Uncoupling protein (UCP) 2 is a member of the uncoupling-protein family, and it appears to function as an uncoupler of oxidative… 
1998
1998
Characterization of human involucrin promoter distal regulatory region transcriptional activator elements-a role for Sp1 and AP1 binding sites.
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