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Genetic, immunologic, and immunohistochemical analysis of the programmed death 1/programmed death ligand 1 pathway in human systemic lupus erythematosus.
OBJECTIVE A putative regulatory intronic polymorphism (PD1.3) in the programmed death 1 (PD-1) gene, a negative regulator of T cells involved in peripheral tolerance, is associated with increasedExpand
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RGS9‐2 is a negative modulator of μ‐opioid receptor function
Regulators of G‐protein signaling (RGS) 9‐2 is a striatal enriched protein that controls G protein coupled receptor signaling duration by accelerating Gα subunit guanosine triphosphate hydrolysis. WeExpand
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Clinical extracorporeal hybrid liver support – phase I study with primary porcine liver cells
Abstract: The objective of this study was to evaluate the feasibility and safety of a hybrid liver support system with extracorporeal plasma separation and bioreactor perfusion in patients with acuteExpand
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Role of RhoB in the Regulation of Pulmonary Endothelial and Smooth Muscle Cell Responses to Hypoxia
Rationale: RhoA and Rho kinase contribute to pulmonary vasoconstriction and vascular remodeling in pulmonary hypertension. RhoB, a protein homologous to RhoA and activated by hypoxia, regulatesExpand
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Physical and functional interactions between members of the tumour suppressor p53 and the Sp families of transcription factors: importance for the regulation of genes involved in cell-cycle arrest
In the present study, we have investigated mechanisms of transcriptional co-operation between proteins that belong to the tumour suppressor p53 and Sp (specificity protein) families of transcriptionExpand
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HDL biogenesis, remodeling, and catabolism.
In this chapter, we review how HDL is generated, remodeled, and catabolized in plasma. We describe key features of the proteins that participate in these processes, emphasizing how mutations inExpand
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Control of transforming growth factor β signal transduction by small GTPases
The integrated roles of small GTPases in executing the transforming growth factor β (TGFβ) signaling pathway have attracted increasing attention in recent years. In this review, we summarize recentExpand
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A common SNP in the CD40 region is associated with systemic lupus erythematosus and correlates with altered CD40 expression: implications for the pathogenesis
Background In systemic lupus erythematosus (SLE) sustained CD40L expression by T cells and platelets activates a variety of cells via its receptor CD40 contributing to disease pathogenesis. AlthoughExpand
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Benefit of warm water immersion on biventricular function in patients with chronic heart failure
BackgroundRegular physical activity and exercise are well-known cardiovascular protective factors. Many elderly patients with heart failure find it difficult to exercise on land, and hydrotherapyExpand
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The role of Sp1 family members, the proximal GC-rich motifs, and the upstream enhancer region in the regulation of the human cell cycle inhibitor p21WAF-1/Cip1 gene promoter.
In the present study we establish that specific members of the Sp1 family of transcription factors (Sp1 and Sp3) bind to all six GC-rich motifs (elements 1-6) present in the proximal promoter of theExpand
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